Pathobiology of digestive diseases

描述（由申请人提供）： 消化系统疾病的病理学是一个程序，在培训博士前和博士后科学家作为合作伙伴与医生在“板凳到床边”消化系统疾病的转化研究20年的经验。为了实现这一目标，我们教育基础和临床科学家对彼此的语言，实验方法，并在他们的领域通过共享教学课程，期刊俱乐部，大轮和研讨会的主要问题。我们的核心病理生物学课程，由医生科学家和基础科学家共同指导，教导我们的学员1）科学发现如何影响临床实践以及临床观察如何影响科学假设，2）批判性地评估有关疾病的现有知识，以及3）使用临床问题作为假设驱动研究的起点。 该计划由生理学教授Laura Liscum博士领导，并资助5名博士前和4名博士后学员。培训由21名导师监督，他们与塔夫茨大学医学院的生理学和分子生物学与微生物学系以及塔夫茨-新英格兰医学中心的医学系有关。教师是基础科学家和医生科学家谁桥梁之间的差距基础细胞生物学和消化系统疾病的差距。他们的工作重点是肝，胰腺，肠和肾的细胞内运输;细胞生长和组织发育;结肠癌和肝癌，乳腺癌转移到肝脏;和肠道病原体。我们的导师坚定地致力于教育，有经验交织基础和临床科学，并直接积极，资金充足的研究计划，解决消化系统疾病的病理生物学。 我们的培训计划是加强了胃肠病学研究中心的吸收和分泌过程（GRASP），一个西尔维奥O。Conte消化疾病核心研究中心，促进对塔夫茨大学胃肠道和肝脏正常功能和疾病的基础研究，并在病理学培训计划中发挥不可或缺的作用。

DESCRIPTION (provided by applicant): Pathobiology of Digestive Disease is a program with 20 years of experience in training predoctoral and postdoctoral scientists to work as partners with physicians in "bench to bedside" translational research on digestive diseases. To achieve this goal, we educate basic and clinical scientists on each other's language, experimental approaches, and the major questions in their field through shared didactic courses, journal club, grand rounds, and seminars. Our core Pathobiology course, co-directed by a physician-scientist and basic scientist, teaches our trainees 1) how scientific discovery has influenced clinical practice and how clinical observation has affected scientific hypotheses, 2) to critically evaluate current knowledge about diseases, and 3) to use clinical problems as a starting point for hypothesis- driven research. The program is led by Laura Liscum, PhD, Professor of Physiology, and funds 5 predoctoral and 4 postdoctoral trainees. Training is supervised by 21 preceptors, who are associated with the Departments of Physiology and Molecular Biology & Microbiology at Tufts University School of Medicine as well as the Department of Medicine at Tufts-New England Medical Center. Faculty members are basic scientists and physician-scientists who bridge the gap between basic cell biology and digestive disease. Their work focuses on intracellular trafficking in the liver, pancreas, intestine and kidney; cellular growth and tissue development; colon and liver cancer, and breast cancer metastasis to liver; and intestinal pathogens. Our preceptors are strongly committed to education, have experience interweaving basic and clinical sciences, and direct active, well funded research programs that address the pathobiology of digestive diseases. Our training program is enhanced by the Center for Gastroenterology Research on Absorptive and Secretory Processes (GRASP), a Silvio O. Conte Digestive Diseases Core Research Center, which promotes basic research on the normal function and diseases of the gastrointestinal tract and liver at Tufts and plays an integral role in the Pathobiology training program.