Narrow spectrum antibiotics for the prevention and treatment of soft-rot plant disease

防治植物软腐病的窄谱抗生素

• 批准号: 2904356
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2904356
• 关键词: Narrow; spectrum; antibiotics; prevention; treatment

Worldwide losses to plant diseases are conservatively estimated at approximately US$150 bn, of which about one third are attributable to bacterial infections. In many cases, good sources of resistance for breeding are not available and the chemicals used to prevent spoilage are increasingly being deemed environmentally unacceptable. We propose a radical new approach to address this problem that exploits the narrow killing spectrum of bacteriocins, potent naturally produced protein antibiotics that can be selected and deployed to target a specific pathogen while leaving the wider plant and soil associated microbiomes intact. In this project, we will identify, produce and test the efficacy in plant infection models of bacteriocins that target soft-rot plant pathogenic bacteria such as species of Pectobacterium. These bacteria cause disease in a range of economically important crops. To achieve this will utilize and provide training in computation biology for genome and phylogenetic analysis, molecular biology, protein production and plant pathology. This work will underpin our long-term vision to utilize diverse bacteriocins for precision targeting of phytopathogenic bacteria, providing a sustainable and practical solution for the prevention and treatment of these recalcitrant plant diseases.

据保守估计，全球植物病害造成的损失约为1500亿美元，其中约三分之一可归因于细菌感染。在许多情况下，没有良好的抗性来源来繁殖，用于防止腐败的化学品越来越被认为是环境上不可接受的。我们提出了一种彻底的新方法来解决这个问题，该方法利用细菌素的狭窄杀伤谱，可以选择和部署天然产生的有效蛋白质抗生素来靶向特定病原体，同时保持更广泛的植物和土壤相关微生物组完整。在本项目中，我们将鉴定、生产和测试针对软腐病植物病原菌（如果胶杆菌属）的细菌素在植物感染模型中的功效。这些细菌在一系列重要的经济作物中引起疾病。为了实现这一目标，将利用和提供计算生物学的基因组和系统发育分析，分子生物学，蛋白质生产和植物病理学的培训。这项工作将支持我们的长期愿景，即利用多种细菌素精确靶向植物病原细菌，为预防和治疗这些植物病害提供可持续和实用的解决方案。