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A novel formulation for combating biofilms and improving orthopaedic surgical wound healing

一种对抗生物膜和改善骨科手术伤口愈合的新型配方

基本信息

批准号：
2905595
负责人：
金额：
--
依托单位：
University of Surrey
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2024
资助国家：
英国
起止时间：
2024 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2905595
关键词：
novel formulation combating biofilms improving

项目摘要

One of the most serious complications following orthopaedic surgery is the development of a deep surgical site infection (SSI) that is due to bacteria contamination from various sources including patients themselves and hospital. The bacteria can exist in planktonic form and in biofilms. The biofilm acts as a physical protective barrier of the bacteria from the penetration of antibodies, bacteriophages, granulocytes and biocides, antiseptics, antibiotics[1] and thus lead to the ineffectiveness of antibiotics and antimicrobial resistance (AMR). This project addresses these challenges through a holistic post surgery wound care approach: early-stage prophylactic intervention through the application of a novel formulation with multiple nutrients to prevent or control planktonic bacteria from proliferation and forming biofilms on both the implant and tissue surfaces. Secondly, this project explores the formulation's potential for the treatment of biofilm induced infection on the surgical site, if it occurs, through the formulation's enhanced biofilm penetration capability and killing resistant bacteria after the biofilm disintegration. Thirdly, certain compounds in the formulation can promote skin tissue regeneration once infection is kept at bay, which could potentially reduce the time taken for wounds recovery and minimise scar tissue formation.

骨科手术后最严重的并发症之一是发生深部手术部位感染（SSI），这是由于各种来源的细菌污染，包括患者本身和医院。细菌可以以浮游形式和生物膜形式存在。生物膜作为细菌的物理保护屏障，防止抗体、噬菌体、粒细胞和杀生物剂、防腐剂、抗生素的渗透[1]，从而导致抗生素无效和抗微生物耐药性（AMR）。该项目通过整体术后伤口护理方法解决这些挑战：通过应用具有多种营养素的新型配方进行早期预防性干预，以防止或控制嗜热细菌增殖并在植入物和组织表面形成生物膜。其次，该项目探索了该制剂用于治疗手术部位生物膜诱导感染的潜力，如果发生这种情况，则通过制剂增强的生物膜渗透能力和在生物膜崩解后杀死耐药细菌。第三，配方中的某些化合物可以促进皮肤组织再生，一旦感染被控制，这可能会减少伤口恢复所需的时间，并最大限度地减少疤痕组织的形成。