CANINE

犬类

• 批准号: 7719683
• 负责人: Donald E. Thrall
• 金额: $ 53.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7719683
• 关键词: Apoptosis; Canis familiaris; Doctor of Philosophy; Dose; End Point; Fever; Fractionation; Funding; Future; Gene Expression; Goals; Heating; High temperature of physical object; Human; Hypoxia; Intercellular Fluid; Invasive; Lead; Length; Malignant Neoplasms; Measurement; Monitor; Necrosis; Pattern; Perfusion; Phase III Clinical Trials; Physiological; Prospective Studies; Protocols documentation; Purpose; Radiation; Radiation therapy; Randomized; Relative (related person); Role; Scheme; Specific qualifier value; Temperature; Testing; Thermometry; Time; Treatment outcome; Tumor Oxygenation; Work; angiogenesis; chemotherapy; cytotoxicity; design; dosimetry; hyperthermia treatment; improved; interstitial; prescription document; prescription procedure; pressure; response; sarcoma; tumor

Hyperthermia has a role in the treatment of tumors but the optinal manner in which to apply heat treatment is not well understood. The purpose of this project is to quantify the physiologic effects of a constant hyperthermia total dose but fractionated using two different prescriptions. This trial arose from our previous work showing an inverse relationship between total duration of heating and length of tumor control. This finding suggests that physiologic changes associated with hypertermia have an influence on treatment outcome and that large thermal doses may be associated with deleterious changes in oxygenation. If hyperthermia use is to be optimized it is important that the physiologic changes associated with hyperthermia frationation be understood. This study will be performed in dogs with spontaneous soft tisue sarcoma. They will receive radiation therapy in addition to hyperthermia. Dogs will be randomized to either a coarsely or finely fractionated hyperthermia prescription. There will be measurements of perfusion, oxygenation, angiogenesis, interstitial pressure and gene expression before treatment and at multiple times during treatment to assess the physiologic effects of heating. Measurements of necrosis and apoptosis will be used to obtain some information on the relative effect of the two fractionation schemes on the tumor. It is anticipated that the more finely fractionated hyperthermia treatment will be associated with more favorable changes in physiologic parameters and increased apoptosis and necrosis compaed to the coarsely fractionated protocol. The information gained from this tiral will be helpful in optimizing the manner in which hyperthermia is used for the treatment of human cancer and for design of future hyperthemria trials.

热疗在肿瘤的治疗中有一定的作用，但应用热疗的最佳方式是