Adolescent Medicine Trials Network for HIV/AIDS Interve*

描述（由申请人提供）：项目概述和相关性：费城儿童医院的青少年试验部门寻求继续与艾滋病毒/艾滋病干预措施青少年试验网络合作。该站点将开展由ATM开发或共同认可的临床研究，重点关注以下方面：1)通过Connect to Protect项目进行初级预防。2)通过ATM临床研究进行二级预防，包括行为和生物医学干预。3)通过ATN临床研究进行三级预防，包括针对感染、患病青年的治疗和行为试验。该网站将实现这些目标如下。“连接保护”项目将通过参与ATN 016B、ATN 040和其他C2P具体研究，继续建立社区动员和伙伴关系。为了实现第二个和第三个目标，该网站将招募和留住艾滋病毒感染者和高危青年进行临床试验。为了成功实现这一目标，该网站将继续开展有针对性的外展和联系方案，以确定感染艾滋病毒的青年，并将他们与护理联系起来。该网站将提供一系列有针对性的多学科服务，为从事研究的青年提供支持。现场PI将继续与TLG合作，制定和实施该网络的治疗议程。其他工作人员将通过参与议定书小组来支持研究议程。最后，网站将通过积极参与电话会议和会议为网络管理做出贡献。该项目处理青少年和青年中艾滋病毒感染的流行问题，为预防新的感染和维护受感染者的健康提供急需的科学数据。ATN开发和实施的临床试验数据将大大有助于了解治疗青少年艾滋病毒感染和预防新感染发生的更好方法。相关性：本项目将对公共卫生产生重大影响。通过精心设计的有针对性的临床试验，将收集急需的数据，以便更好地了解如何预防青少年和年轻人中新的艾滋病毒感染的传播。对感染艾滋病毒的青少年和青壮年进行的试验将提供必要的数据，以便通过改进对受感染者的管理战略，防止艾滋病毒从受感染者那里传播。

DESCRIPTION (provided by applicant): Project Summary and Relevance: The Adolescent Trials Unit at The Children's Hospital of Philadelphia seeks to continue their work with the Adolescent Trials Network for HIV/AIDS Interventions. The site will conduct clinical studies developed or co-endorsed by the ATM that will focus on the following: 1) primary prevention through the Connect to Protect project. 2) secondary prevention through ATM clinical studies including both behavioral and biomedical interventions. 3) tertiary prevention through ATN clinical studies including therapeutic and behavioral trials targeting infected, ill youth. The site will accomplish these goals as follows. The Connect to Protect Project will continue to build community mobilization and partnerships through participation in ATN 016B, ATN 040,and other C2P specific studies. To address the second and third aims, the site will recruit and retain HIV-infected and at-risk youth into clinical trials. To accomplish this goal successfully, the site will continue with their targeted outreach and linkage program to identify HIV infected youth and link them to care. The site will provide a broad array of targeted, multi disciplinary services to support youth once engaged in research. The site PI will continue to work with the TLG to develop and implement the therapeutic agenda of the Network. Other staff will support the research agenda through participation on protocol teams. Finally, the site will contribute to the Network management through active participation in conference calls and meetings. This project addresses the epidemic of HIV infection in adolescents and young adults to provide the much-needed scientific data to prevent new infections and maintain the health of those infected. The data from the clinical trials developed and implemented by the ATN will contribute significantly to understanding better ways to treat HIV infection in adolescents and prevent new infections from occurring. Relevance: This project will have major public health implications. Through well designed targeted clinical trials, the much needed data will be collected to learn better how to prevent the spread of new HIV infections in adolescents and young adults. The trials with HIV-infected adolescents and young adults will provide data required to prevent the spread of HIV from infected persons through better management strategies for infected individuals.