Clinical Science Research Core B

临床科学研究核心B

• 批准号: 7116099
• 负责人: BRUCE W PATTERSON
• 金额: $ 26.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116099
• 关键词: biomedical facility; body composition; clinical research; health science research support; magnetic resonance imaging; metabolism; nutrition; photon absorptiometry; positron emission tomography; training

The purposes of the Clinical Science Research Core are: 1) to enhance and facilitate nutrition-related clinical research, 2) to provide training for young investigators in such research, and 3) to provide basic researchers with ready access to clinical research technology so that hypotheses based on non-human models can be tested in humans. Moreover, it is expected that the Clinical Science Research Core will play a central role in stimulating patient-oriented nutrition research at Washington University. The Clinical Science Research Core will provide state-of-the-art methods and services to support clinical research organized through three sub-cores: Metabolic Kinetics Sub-core (stable isotope tracers and mathematical modeling of metabolic kinetics); Body Composition and Metabolic Imaging Sub-core (Mangnetic resonance imaging (MRI), Magnetic resonance spectroscopy (MRS), Positron emission tomography (PET), Dual energy x-ray absorptiometry (DEXA); Cardiovascular Assessment Sub-core (endothelial function, carotid artery intima-media thickness, echocardiograms, indirect calorimetry, exercise assessment and training). A large number of current and future research projects will require the use of all 3 sub-cores for a complete characterization of subjects. The consolidation of these services within one Core will help ensure overall quality, limit inappropriate research efforts, increase cost-effectiveness and facilitate the use of a range of services that would otherwise be difficult for investigators to obtain.

临床科学研究核心的目的是：1）加强和促进与营养有关的 临床研究，2）为此类研究中的年轻研究人员提供培训，以及3）提供基本的 研究人员随时可以获得临床研究技术，以便基于非人类的假设 模型可以在人类身上进行测试。此外，预计临床科学研究核心将发挥 在促进华盛顿大学以病人为导向的营养研究中发挥核心作用。 临床科学研究核心将提供最先进的方法和服务，以支持临床 通过三个分核心组织的研究： 代谢动力学子核心（稳定同位素示踪剂和代谢动力学的数学建模） 动力学）; 身体成分和代谢成像子核心（磁共振成像（MRI）， 磁共振波谱（MRS）、正电子发射断层扫描（PET）、双能量 X线吸收法（DEXA）; 心血管评估子核心（内皮功能、颈动脉内膜-中层 厚度、超声心动图、间接测热法、运动评估和训练）。 大量当前和未来的研究项目将需要使用所有3个子核来实现完整的 主题的特征。将这些服务整合到一个核心内将有助于确保 质量，限制不适当的研究努力，提高成本效益，并促进使用一系列 调查人员难以获得的服务。