Wireless System-on-a-Chip EEG IC For Animal Studies

描述（由申请人提供）：AME提议开发和测试重量小于4克的多通道数字无线头台，用于包括小鼠在内的小动物神经学研究。目前的无线耳机对于鼠标来说太重了。该设备将通过小鼠研究，推动无线动态动物神经监测技术的发展，从而填补重要的市场空白。它还将使新的神经学研究成为可能。由于小鼠在基因上是可操纵的，它们可以进行在其他物种（如大鼠）身上无法进行的科学实验。该设备将支持详细的动物神经学研究，支持许多研究领域，包括阿尔茨海默氏症，亨廷顿氏病和癫痫。由于低功耗、高数据速率的无线无线电技术的发展，数字无线耳机最近才成为可能。美国一家主要的半导体制造商最近一直在开发用于植入式设备和助听器的高数据速率无线电技术，该技术需要最小的外部组件和低功率（~1mW）。功耗比蓝牙等其他无线解决方案低一个数量级以上，蓝牙已被提出用于大鼠头台。这种低功率无线电技术是实现数字无线头台的必要条件，同时满足对老鼠头台严格的低重量要求。第二阶段将制造定制IC，混合电路板和模塑塑料封装，以实现设备的产品化。将采用耳内式助听器组件常用的技术来实现低质量。最终装置将被全面评估。该设备将支持详细的动物神经学研究，支持许多研究领域，包括阿尔茨海默氏症，亨廷顿氏病和癫痫。

DESCRIPTION (provided by applicant): AME proposes to develop and test a multi-channel digital wireless headstage that weighs less than 4 grams for use in small animal neurological studies including mice. Current wireless headstages are too heavy for mice. The proposed headstage will advance the state-of-the-art in wireless ambulatory animal neurological monitoring by enabling mouse studies, and, thus, filling an important marketplace void. It will also enable new neurological research. Because mice are genetically manipulable, they accommodate scientific experiments that are unavailable in other species, such as rats. This device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy. A digital wireless headstage for mice has only recently been made possible due to developments in very low power, high data rate, wireless radios. A major US semiconductor manufacturer has recently been developing high data rate radio technology for implantable devices and hearing aids requiring minimal external components and low power (~1mW). The power consumption is more than an order of magnitude lower than other wireless solutions, such as Bluetooth, which has been proposed for rat headstages. This low power radio technology is necessary to achieve a digital wireless headstage while meeting the strict low weight requirements of headstages for mice. The phase II will fabricate a custom IC, the hybrid circuit board and the molded plastic package to productize the device. Techniques common to in-the-ear hearing aid assembly will be used achieve the low mass. The final device will be fully evaluated. This device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy.