CORE--ANALYTICAL LABORATORY

该设备为中心研究人员的研究兴趣相关分子提供经济、准确的化学分析。它也是与分析化学中分析物的定量和策略有关的咨询的基础。我们提供先进的技术服务和专业知识，包括最先进的技术，特别是液相色谱质谱（LC/MS）和气相色谱质谱（GC/MS）。此外，常规分析和临床标志物的测定提供给调查员。在夏威夷州，没有其他实验室可以提供这些服务。通过参加内部和外部质量保证方案，包括参加由国家标准与技术研究所组织的循环测试，不断监测高质量的服务。这种共享资源的可用性提供了最先进的服务，改善了对研究人员的反馈，促进了跨学科合作，并为CRCH研究人员提供了更具成本效益的服务。预计在可预见的未来，目前的满负荷使用将继续下去。需要该资源服务的新资助项目将超过在来年终止的项目。在本周期内，通过CCSG支助赠款获得的设备大大提高了这一资源的潜力。该设施自成立以来取得了显著的增长，其对中心研究的价值体现在其广泛的使用上，目前为所有三个项目的11名CRCH研究人员提供服务，过去四年的服务产出增长了两倍多，并在01- 04财年利用共享资源发表了32篇同行评议手稿。

This facility provides cost-effective and accurate chemical analyses for molecules relevant to research interests of Center investigators. It is also a base for consultation related to the quantisation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LC/MS) and gas chromatography mass spectrometry (GC/MS). In addition routine analyses and determinations of clinical markers are offered to investigators. No other laboratories are available to provide many of these services in the State of Hawaii. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this Shared Resource provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides more cost-effective service to CRCH investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming year. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth since its inception and its value to Center research is reflected in its broad usage, currently servicing eleven CRCH investigators from all three Programs, more than a twofold increase in service output the past four years, and the publication of 32 peer reviewed manuscripts in FY01-FY04 utilizing the shared resource.