Sensory Processing in the Mouse Accessory Olfactory Bulb

描述（由申请人提供）：感觉处理的中断对与诸如阿尔茨海默病或神经性中风的疾病相关的发病率有显著贡献，但对这种处理的神经基础知之甚少。老鼠用来识别信息素的嗅觉系统的划分提供了感觉处理的基本任务的例子，但是在一组神经结构中进行，这些神经结构在解剖学上比大多数哺乳动物的感觉系统更简单，更容易接近。分离刺激转导和行为输出的有限数量的处理位置使得该系统对于探索感觉系统提取关于自然刺激的显著特征的信息的机制特别有用，并以可用于指导行为的形式表示它们。测量该系统的二阶神经元在呈现自然刺激期间的活动有可能测试关于如何在嗅觉系统中实施这些机制的一些假设。将通过细胞外记录测量该细胞群的活性。

DESCRIPTION (provided by applicant): Disruptions in sensory processing contribute significantly to the morbidity associated with diseases such as Alzheimer's Disease or following a neurological stroke, yet the neural basis of this processing is poorly understood. The division of the olfactory system used by mice to recognize pheromones provides examples of the basic tasks of sensory processing, but carried out in a set of neural structures that are anatomically simpler and more accessible than most mammalian sensory systems. The limited number of processing locations separating stimulus transduction and behavioral output make this system particularly useful for exploring the mechanisms by which sensory systems extract information about the salient characteristics of natural stimuli, and represent them in a form that can be used to guide behavior. Measuring the activity of the second order neurons of this system during the presentation of natural stimuli has the potential to test a number of hypotheses about how such mechanisms are implemented in the olfactory system. The activity of this cell population will be measured through extracellular recordings.