Chronic Prostatitis Collaborative Clinical Trials

本申请反映了布里格姆妇女医院（BWH）和马萨诸塞州的建议 综合医院（MGH）/哈佛医学院成为慢性 前列腺炎合作研究网络（CPCRN）开发和进行随机临床试验， 评估慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS）患者的新疗法。 BWH/MGH哈佛临床中心有成功招募和保留CP/CPPS的历史 1997年CPCRN中来自新英格兰地区的患者，包括很大比例的拉丁裔患者- 2003年-慢性前列腺炎队列研究和随机临床试验。玛丽博士 McNaughton柯林斯和Michael O 'Leary通过帮助开发和 验证NIH-慢性前列腺炎症状指数，将该指数翻译成西班牙语，评估质量 CP/CPPS男性的生活和资源利用，以及检查流行病学和自然 该疾病的病史。McNaughton柯林斯博士还进行了几项慢性前列腺炎研究， 前列腺疾病患者结局研究小组（PORT）和科克伦的成员 协作 BWH/MGH哈佛临床中心已扩大到包括多机构和多学科 共同研究者和顾问网络，慢性前列腺炎，疼痛管理） 专门知识和方法（即，临床试验、基础科学和成果研究）培训，以及 慢性前列腺炎患者的新鲜来源，特别是新诊断患者和少数民族患者。的 新的CP/CPPS患者库包括：1）来自初级保健的新诊断的CP/CPPS患者 两个大型机构及其社区卫生中心的实践和医疗无障碍单位， 包括BWH内科西班牙诊所; 2）新诊断和长期CP/CPPS 来自MGH西班牙泌尿科诊所的患者，以及; 3）来自MGH西班牙泌尿科诊所的新诊断和长期患者 波士顿医疗中心，这是一个大型的，市中心的学术健康中心，提供护理，以一个大的 非裔美国人的比例。为了帮助招募和留住拉丁裔男子，该网站 现在包括3名讲西班牙语的医学和泌尿学研究人员，研究协调员是 上西班牙语课以精通西班牙语该提案包括临床试验设计供考虑 的CPCRN。来自BWH/MGH哈佛临床的多机构、多学科团队 中心渴望与其他CPCRN中心合作进行治疗试验和辅助研究， NIH/NIDDK科学团队和间质性膀胱炎临床试验组。

This application reflects a proposal from the Brigham and Women's Hospital (BWH) and Massachusetts General Hospital (MGH) / Harvard Medical School to become one of the Clinical Centers of the Chronic Prostatitis Collaborative Research Network (CPCRN) to develop and conduct randomized clinical trials for evaluating novel therapies in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The BWH/MGH Harvard clinical center has a history of successful recruitment and retention of CP/CPPS patients, including a substantial proportion of Latino patients, from the New England area for CPCRN 1997- 2003 - both for the Chronic Prostatitis Cohort Study and Randomized Clinical Trial. Drs. Mary McNaughton Collins and Michael O'Leary have advanced the field of CP/CPPS by helping to develop and validate the NIH-Chronic Prostatitis Symptom Index, translating the index to Spanish, evaluating the quality of life and resource utilization of men with CP/CPPS, as well as examining the epidemiology and natural history of the condition. Dr. McNaughton Collins has also performed several chronic prostatitis studies as a member of the Patient Outcomes Research Team (PORT) for Prostate Diseases and the Cochrane Collaboration. The BWH/MGH Harvard clinical center has expanded to include a multi-institutional and multi-disciplinary network of co-investigators and consultants with both content (i.e., chronic prostatitis, pain management) expertise and methodological (i.e., clinical trials, basic science, and outcomes research) training, as well as fresh sources of chronic prostatitis patients, especially newly diagnosed patients and minority patients. The new reservoirs of CP/CPPS patients include: 1) newly diagnosed CP/CPPS patients from primary care practices and medical walk-in units across the two large institutions and their neighborhood health centers, including the BWH internal medicine Spanish clinic; 2) both newly diagnosed and long-term CP/CPPS patients from the MGH Spanish urology clinic, and; 3) both newly diagnosed and long-term patients from Boston Medical Center, which is a large, inner-city academic health center providing care to a large proportion of African American patients. To assist in the recruitment and retention of Latino men, the site now includes 3 Spanish speaking medicine and urology investigators, and the Research Coordinator is taking Spanish classes to become proficient. This proposal includes a clinical trial design for consideration by the CPCRN. The multi-institutional, multi-disciplinary team from the BWH/MGH Harvard clinical center is eager to collaborate on treatment trials and ancillary studies with other CPCRN centers, the NIH/NIDDK scientific team, and the Interstitial Cystitis Clinical Trials Group.