Arizona Center for Education and Research on Therapeutics

亚利桑那治疗学教育与研究中心

• 批准号: 7339910
• 负责人: Raymond Leon Woosley
• 金额: $ 99.05万
• 依托单位: CRITICAL PATH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339910
• 关键词: Arizona; Center; Education; Research; Therapeutics

DESCRIPTION (Provided by the Applicant): The Arizona CERT (AzCERT) is a consortium of the University of Arizona (UA) and the Critical Path Institute (C-Path), a non-profit organization in Tucson, AZ. The AzCERT has six years of experience in the prevention of adverse drug reactions (ADDRs) associated with drug-drug interactions (DDIs), especially those that harm women. This application expands on this theme using a systems approach to examine the underlying human and systems factors responsible for the co-prescription, co-dispensing and co-administration of drug combinations that have the potential to interact (PDDIs) and cause ADDRs. Our specific aims are to 1) improve patient safety by reducing PDDIs and 2) improve health outcomes by reducing ADDRs. Research will examine the effectiveness of provider-targeted and patient-targeted interventions on PDDIs and ADDRs. The AzCERT will continue its very productive collaborations with the Veterans Administration Healthcare System to evaluate the effectiveness of alerts to physicians for preventing PDDIs and ADDRs. We will also evaluate the effectiveness of a "near real time" fax alert program that includes Medicare Part D prescribers for prevention of PDDIs and ADDRs in medication management call centers (UA and Caremark). We will evaluate innovative PDDI educational interventions that take place in community settings, including clinical laboratories and community health centers (CHC) and capture the "teachable moment" when patients are waiting to have blood drawn for monitoring warfarin, digoxin and other drug therapies. AzCERT will develop and evaluate innovative "train-the-trainer" programs as part of the inter-professional curriculum in the UA colleges of nursing, medicine and pharmacy. The AzCERT has well-established international (web-based), national, regional and community educational and dissemination programs that are based on research conducted by AzCERT and others. The internationally recognized website, QTdrugs.org (360,000 visits in 2005) will be expanded and made more interactive through collaborations with the FDA, Lincoln Technologies and DrugLogic. Together with the FDA, AMA and the American College of Clinical Pharmacology, we will inform providers and patients about DDI and new gene-based dosing for warfarin through multiple approaches including a new website, www.warfarin-ddi.org. In this application, we will greatly expand our dissemination efforts to include public service announcements featuring former U.S. Surgeon General Richard Carmona. All of this work will focus on evidence-based, culturally sensitive interventions, thorough evaluation and dissemination of information that is relevant to patients, especially the Hispanic, Native American and under-served urban and rural populations in AZ. Dissemination will be facilitated by collaborative relationships with the AZ Association of CHCs, clinical laboratories, the Area Health Education Centers (AHEC), UA College of Agriculture Cooperative Extension and Cox Cable. The AzCERT will leverage the federal funding for this grant through partnerships that extend our reach and our ability to improve health outcomes for patients.

描述(由申请人提供)：亚利桑那州CERT(AzCERT)是由亚利桑那大学(UA)和位于亚利桑那州图森市的非营利性组织关键路径研究所(C-PATH)组成的联盟。AzCERT在预防与药物相互作用相关的药物不良反应(ADDR)方面拥有六年的经验，特别是那些伤害妇女的药物不良反应。本申请使用系统方法对这一主题进行扩展，以检查导致可能相互作用(PDDIs)和导致ADDR的药物组合的共同处方、共同分配和共同管理的潜在人为和系统因素。我们的具体目标是1)通过减少PDDIs来提高患者的安全性，以及2)通过减少ADDR来改善健康结果。研究将检查以提供者为目标和以患者为目标的干预对PDDIs和ADDR的有效性。AzCERT将继续与退伍军人管理局医疗保健系统进行卓有成效的合作，以评估向医生发出的警报对预防PDDIs和ADDR的有效性。我们还将评估“近实时”传真警报计划的有效性，该计划包括Medicare Part D处方者，用于在药物管理呼叫中心(UA和Caremark)预防PDDIs和ADDR。我们将评估发生在社区环境中的创新的PDDI教育干预措施，包括临床实验室和社区卫生中心(CHC)，并捕捉患者等待抽血以监测华法林、地高辛和其他药物治疗的“可教时刻”。AzCERT将开发和评估创新的“培训者培训”计划，作为亚利桑那州护理、医学和药学学院跨专业课程的一部分。AzCERT有完善的国际(基于网络)、国家、区域和社区教育和传播方案，这些方案基于AzCERT和其他机构进行的研究。通过与FDA、林肯技术公司和DrugLogic公司的合作，国际公认的网站QTdrags.org(2005年的访问量为360,000次)将得到扩大，并使其具有更强的互动性。我们将与FDA、AMA和美国临床药理学学院一起，通过包括新网站www.warfarin-ddi.org在内的多种途径，向供应商和患者通报DDI和新的基于基因的华法林剂量。在这项申请中，我们将极大地扩大我们的传播努力，以包括以前美国卫生局局长理查德·卡莫纳为主角的公共服务公告。所有这些工作将侧重于循证、文化敏感的干预措施，彻底评估和传播与患者相关的信息，特别是亚利桑那州的西班牙裔、美洲原住民和服务不足的城市和农村人口。传播将通过与亚利桑那州卫生保健协会、临床实验室、地区健康教育中心(AHEC)、亚利桑那州农业学院合作推广和COX电缆的合作关系来促进。AzCERT将通过合作伙伴关系利用这笔赠款的联邦资金，以扩大我们的覆盖范围和我们改善患者健康结果的能力。