fMRI Studies in Adolescents At-Risk for Schizophrenia

对有精神分裂症风险的青少年进行功能磁共振成像研究

• 批准号: 7119652
• 负责人: Vaibhav A. Diwadkar
• 金额: $ 12.41万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-20 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7119652
• 关键词: adolescence (12-20); behavioral /social science research tag; bioimaging /biomedical imaging; brain morphology; clinical research; developmental neurobiology; disease /disorder proneness /risk; family genetics; functional magnetic resonance imaging; human subject; neuropsychological tests; neuropsychology; patient oriented research; saccades; schizophrenia; short term memory

DESCRIPTION (provided by applicant): The aim of this career development proposal is to allow the applicant to acquire the skills necessary to characterize neurodevelopmental abnormalities associated with adolescents at risk for schizophrenia. Schizophrenia is a highly debilitating and complex disorder marked by severe abnormalities in cognitive function, particularly working memory. The illness may be mediated by neurodevelopmental abnormalities and by genetic factors. Studies of neurodevelopment in adolescent first-degree relatives who are at significantly elevated risk for developing the illness promise to help better elucidate the premorbid diatheses of the illness. This proposal will use fMRI to investigate working memory abnormalities in adolescent first-degree relatives of schizophrenia patients. The use of fMRI will facilitate an understanding of alterations in the functional neuroarchitecture of these subjects and fill a lacuna in the present understanding of the precursors of the illness. The analysis of the fMRI data will focus on identifying regions of aberrant activation, as well as probing functional disconnections between regions of the brain. Relationships between aberrant fMRI activation and structural alterations in the brain will also be explored. During the course of this award, the applicant will obtain training in: 1) understanding developmental neuroscience during the period of adolescence, 2) the use of fMRI for the study of adolescent high-risk populations 3) understanding of the clinical issues associated with schizophrenia, particularly its premorbid and prodromal phases, 4) understanding of statistical, ethical and epidemiological issues associated with the field neuropsychiatric research. By the conclusion of the award, the applicant expects to emerge as an expert on the application of neuroimaging to the study of the neurobiological precursors of schizophrenia. The proposal's focus promises to provide better insights into the developmental neurobiology of the illness and the contributions of development and genetics. The data will help the applicant develop larger projects during the concluding years of the award period that may help in the development of psychosocial and psychopharmacologic interventions in adolescents at risk for schizophrenia.

描述（由申请人提供）：这项职业发展建议的目的是允许申请人获得表征与患有精神分裂症风险的青少年相关的神经发育异常所必需的技能。 精神分裂症是一种高度令人衰弱和复杂的疾病，具有认知功能，尤其是工作记忆的严重异常。该疾病可能是由神经发育异常和遗传因素介导的。在青少年一级亲戚中对神经发育的研究显着增加了疾病的风险，有助于更好地阐明疾病的病前核心。该提案将使用fMRI研究精神分裂症患者青少年一级亲戚的工作记忆异常。 fMRI的使用将有助于理解这些受试者功能性神经结构的改变，并在对疾病前体的当前理解中填补空白。 FMRI数据的分析将集中在识别异常激活区域，以及探测大脑区域之间的功能断开连接。还将探讨异常功能磁共振成像激活与大脑结构改变之间的关系。 During the course of this award, the applicant will obtain training in: 1) understanding developmental neuroscience during the period of adolescence, 2) the use of fMRI for the study of adolescent high-risk populations 3) understanding of the clinical issues associated with schizophrenia, particularly its premorbid and prodromal phases, 4) understanding of statistical, ethical and epidemiological issues associated with the field neuropsychiatric research.通过该奖项的结论，申请人预计将成为神经成像应用于精神分裂症神经生物学前体的专家。该提案的重点有望更好地了解疾病的发育神经生物学以及发育和遗传学的贡献。这些数据将帮助申请人在奖励期的结论年中开发较大的项目，这可能有助于发展有精神分裂症风险的青少年的心理和心理药物干预措施。