Neurotransmitter Function, Psychiatric Disorders, & MRS

描述(申请人提供)：本次研讨会将主要集中在精神障碍，包括情绪障碍，精神分裂症，以及滥用物质，如酒精和尼古丁。讲习班有三个主要目标：(1)主要参与技术开发的研究人员和专注于神经精神病学研究的研究人员之间交流思想和信息。(2)精神病学应用研究人员的技术教育。(3)对技术型科研人员进行心理药理学和病因学教育。与会者将包括来自技术和应用领域的知名研究人员，但将特别强调鼓励年轻研究人员出席和参与。方法：该计划将包括为期两天半的研讨会的国际演讲者名单。预计观众将包括来自世界各地的150-250名研究人员。拟议的会议日期为10月13日至15日。拟议的议程将包括两个主要主题：神经精神障碍中的神经递质功能：病理生理学和在治疗中的作用，以及磁共振波谱(MRS)的方法。两天半会议的大致大纲是：会议前一晚的介绍性讲座：非常基础的MRS：什么是Spin？什么是垫片？我们怎么才能收到信号？全体会议报告：关于精神障碍，我们需要知道什么？一般的成像，特别是光谱学，如何帮助我们更多地了解关键问题领域？与精神障碍相关的神经回路和神经递质功能的综述。关于每一种MRS方法和精神病学应用的全体会议：教学演讲(每个30“)，然后提供关于当前研究的评论论文(每个10分钟)，以开放讨论结束。治疗的新方向和应用：关于临床应用的演讲，从基础研究到制药工业的过渡。评论：主题将包括诊断和治疗成功的预测因素；治疗的标志物；神经回路；细胞内靶点；基因表达等。摘要的呼吁将提出其他小组的名字和想法，可能会添加到主程序中。青年调查员旅行奖是这一计划的重要组成部分。《生物医学核磁共振》的编辑Chris Boesch已经同意考虑发表在会议上发表的关于尖端工作的同行评议论文。磁共振波谱(MRS)是一种成像技术，其尖端应用可能会给临床研究人员带来可怕的技术障碍，而我们对神经递质功能和调节的知识已经达到了一个点，在这一点上，经过技术培训的MRS研究人员可能缺乏临床应用知识，以及与应用其先进技术相关的问题。这次研讨会将促进这两个领域的研究人员的交叉教育，这是最大限度地提高精神障碍神经递质功能翻译研究的机会和质量所必需的。

DESCRIPTION (provided by applicant): This workshop will be focused primarily on psychiatric disorders, including mood disorders, schizophrenia, and abuse of substances such as alcohol and nicotine. The workshop has three primary goals: (1) Exchange of ideas and information between investigators involved primarily in technical development and those focused on neuropsychiatric research. (2) Technical education for psychiatric applications researchers. (3) Psychopharmacologic and etiologic education for technically oriented researchers. Attendees will include established researchers from technical and applications areas, but a special emphasis will be made to encourage attendance and participation by young investigators. METHODS: The program will include an international roster of speakers in a two and a half-day symposium. The audience is expected to include 150-250 researchers from around the world. The proposed meeting dates are October 13-15. The proposed agenda will include 2 main topics: Neurotransmitter function in neuropsychiatric disorders: pathophysiology and role in treatment, and Methods of Magnetic Resonance Spectroscopy (MRS). A general outline for the two and a half day meeting is: Introductory Lecture night before conference: Very basics of MRS: What is spin? What is shimming? How do we get a signal? Plenary Presentations What do we need to know about psychiatric disorders? How can imaging in general and spectroscopy in particular, help us learn more about key problem area? Review of neurocircuitry and neurotransmitter function related to psychiatric disorders. Plenary Sessions on each of the MRS methods and psychiatric applications: Teaching talks (30" each) followed by proffered, reviewed papers on current research (10 min each), concluding with open discussion. New Directions and Applications to Treatment: Talks on clinical applications, transition from basic research to pharmaceutical industry. COMMENTS: Topics will include predictors of diagnosis and treatment success; markers for treatment; neurocircuitry; intracellular targets; gene expression, etc. A call for abstracts will bring forward names and ideas from other groups that might be added to the main program. Young Investigator travel awards form an important part of this program. The editor of NMR in Biomedicine, Chris Boesch, has agreed to consider publishing peer-reviewed papers on cutting-edge work presented in the sessions in the conference. Magnetic resonance spectroscopy (MRS) is an imaging technology whose cutting edge applications can pose an intimidating technological barrier to clinical researchers, and our knowledge of neurotransmitter function and regulation has reached a point at which technically trained MRS researchers may lack knowledge of clinical applications and associate issues to apply their advanced techniques. This workshop will promote the cross-education of investigators from both areas, which is necessary to maximize the opportunities for and quality of translational research on neurotransmitter function in psychiatric disorders.