Progesterone as a Treatment for Cocaine Abuse in Rats with Differing Vulnerabilit

黄体酮治疗不同易感性大鼠的可卡因滥用

• 批准号: 7274016
• 负责人: JUSTIN Jack ANKER
• 金额: $ 3.54万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2010-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274016
• 关键词: Abbreviations; Accident and Emergency department; Affect; Alcohols; Allopregnanolone; Animals; Anti-Anxiety Agents; Asses; Avidity; Behavior; Cocaine; Cocaine Abuse; Condition; Crack Cocaine; Data; Dependence; Drug abuse; Effectiveness; Estrogens; Female; Food; Gonadal Hormones; Health; Hormonal; Hospitals; Impulsivity; Individual; Injection of therapeutic agent; Intake; Maintenance; Measures; Motivation; Motor Activity; Ovarian hormone; Ovariectomy; Pharmaceutical Preparations; Phase; Phenotype; Play; Population; Process; Progesterone; Psychological reinforcement; Rate; Rattus; Relapse; Relative (related person); Reporting; Research; Resistance; Role; Running; Saccharin; Schedule; Self Administration; Sex Characteristics; Specificity; Treatment outcome; United States Substance Abuse and Mental Health Services Administration; Visit; Woman; Work; addiction; craving; discounting; effectiveness research; excessive behavior; male; men; reinforced behavior; reinforcer; research study; sex; therapeutic effectiveness; treatment effect

DESCRIPTION (provided by applicant): Sex differences exist in drug abusing populations. In addition, it has been shown that the female gonadal hormones, estrogen and progesterone, modulate behavior elicited by cocaine in different and sometimes opposite ways. The primary aim of the proposed research is to examine the effects of progesterone on the inhibition of cocaine-seeking behavior in rats. In the proposed research, the effectiveness of progesterone as a treatment will be examined in the escalation and maintenance phases of the addiction process. The self-administration paradigm will be used to asses these effects. The following are specific aims that correspond to the 3 proposed self-administration experiments: Aim 1 - to examine the influence of progesterone treatment in male and female rats on responding under a progressive ratio schedule and during escalation of drug intake due to extended access. The effects of progesterone treatment on nondrug reinforcers will also be examined to assess progesterone's therapeutic specificity. Aim 2 - to assess the therapeutic effectiveness of progesterone as a treatment in populations that differ in the vulnerability to cocaine-seeking behavior. These populations include: male vs. female, high vs. low impulsive, and high vs. low saccharin preferring rats. Aim 3 - to examine the effects of one of progesterone's behaviorally active, metabolites, allopregnanolone, during the escalation of cocaine intake. The proposed research will also assess the effectiveness of progesterone and allopregnanolone as potential treatments for cocaine abuse in more and less vulnerable phenotypes.

描述（由申请人提供）：吸毒人群存在性别差异。此外，研究表明，女性性腺激素，雌激素和孕激素，以不同的、有时相反的方式调节可卡因引起的行为。本研究的主要目的是研究黄体酮对大鼠可卡因寻求行为的抑制作用。在拟议的研究中，黄体酮作为一种治疗的有效性将在成瘾过程的升级和维持阶段进行检查。自我管理范式将用于评估这些影响。以下是与3个拟议的自我给药实验相对应的具体目标：目标1 -检查孕酮治疗对雄性和雌性大鼠在渐进比例计划下的反应的影响，以及在药物摄入因延长而增加的过程中。黄体酮治疗对非药物强化剂的影响也将被检查，以评估黄体酮的治疗特异性。目的2：评估黄体酮在易受可卡因寻求行为影响人群中的治疗效果。这些种群包括：雄性与雌性，高冲动与低冲动，高糖精偏好与低糖精偏好。目的3：研究在可卡因摄入增加过程中，孕酮的一种行为活性代谢产物异孕酮的影响。拟议的研究还将评估黄体酮和异孕酮作为可卡因滥用或多或少易感表型的潜在治疗方法的有效性。