Fluoxetine Versus Bupropion in Suicide Attempters With Major Depressive Disorder
氟西汀与安非他酮治疗患有重度抑郁症的自杀未遂者
基本信息
- 批准号:7176838
- 负责人:
- 金额:$ 17.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-02-06 至 2011-01-31
- 项目状态:已结题
- 来源:
- 关键词:Admission activityAggressive behaviorAllelesAmericanAntidepressive AgentsAreaAttentionAwardBupropionCause of DeathClinicalClinical TrialsClinical Trials DesignConsultationsDepressed moodDepression and SuicideDevelopmentDiagnostic and Statistical ManualDisease susceptibilityDouble-Blind MethodEventFeeling suicidalFluoxetineFrequenciesGenesGeneticGenetic PolymorphismGenetic VariationGenotypeGoalsHospitalsImpulsivityK-Series Research Career ProgramsKnowledgeMajor Depressive DisorderMeasuresMediatingMental DepressionMental disordersMentorsMentorshipMethaqualoneMethodsMood DisordersMoodsNeurobiologyNeuropsychological TestsPatientsPersonsPharmaceutical PreparationsPharmacogeneticsPrincipal InvestigatorProcessPurposeRandomizedRecording of previous eventsResearchResearch PersonnelResearch Project GrantsRiskRisk FactorsSamplingSerotonin AgentsSeveritiesStatistical MethodsSuicideSuicide attemptSuicide preventionTherapeutic EffectTrainingVariantWorkcareerdisabilityexperiencegenetic epidemiologyimprovedknowledge basemaleneuropsychologicalpatient orientedpreventprogramspromoterresearch and developmentresponsesexsingle episode major depressive disorderskillssuicidalsuicidal actsuicidal behaviorsuicidal risktrial comparing
项目摘要
DESCRIPTION (provided by applicant): Major depressive disorder (MOD) is a common and serious psychiatric illness. It is among the leading causes of disability and is the psychiatric disorder most frequently associated with suicide. Yet the treatment of MOD with antidepressant medication remains largely a trial-and-error process and little empirical evidence exists to guide treatment when suicide prevention is a priority. The purpose of this patient-oriented K-award is to develop and execute a program of research that will investigate clinical, neuropsychological and genetic predictors of response to different types of antidepressant medications in a high-risk sample of persons with MOD and a history of suicide attempt. Changes in clinical and neuropsychological components of depression and the diathesis for suicide will be compared during treatment with a serotonergic versus a non- serotonergic antidepressant. We will also determine whether functional polymorphisms in genes related to depression or the diathesis for suicide predict therapeutic effects of these antidepressants on mood or components of the diathesis for suicide. The principal investigator will carry out this program of research career development under the strong mentorship of Dr. J. John Mann (for training in the clinical neurobiology of depression and suicide). Active consultation and additional mentorship will come from Dr. A. John Rush (for training in antidepressant clinical trial design and execution), Dr. Bruce G. Pollock (for training in antidepressant pharmacogenetics), Dr. Joseph D. Terwilliger (for training in genetic epidemiology), Dr. John Keilp (for training in use of neuropsychological tests) and from Dr. Eva Petkova (for training in statistical analytic methods). This patient-oriented career development award will provide the principal investigator with the further experience and skills necessary to integrate clinical and scientific expertise in the field of depression and suicide clinical trials research. The long-term goal of this award is for the candidate to become an expert and independent clinical researcher on the treatment of depression with a special focus on suicide prevention.
描述(申请人提供):严重抑郁障碍(MOD)是一种常见和严重的精神疾病。它是导致残疾的主要原因之一,也是最常与自杀有关的精神障碍。然而,使用抗抑郁药物治疗MOD在很大程度上仍然是一个反复试验的过程,当自杀预防被优先考虑时,几乎没有经验证据来指导治疗。这项以患者为导向的K奖的目的是开发和执行一项研究计划,该计划将在有自杀未遂病史的MOD高危患者样本中调查不同类型抗抑郁药物反应的临床、神经心理学和遗传预测因素。在使用5-羟色胺能和非5-羟色胺能抗抑郁药治疗期间,将比较抑郁症的临床和神经心理成分的变化以及自杀的素质。我们还将确定与抑郁或自杀素质相关的基因的功能多态性是否可以预测这些抗抑郁药物对情绪或自杀素质成分的治疗效果。首席研究员将在J.John Mann博士(抑郁症和自杀的临床神经生物学培训)的大力指导下开展这一研究职业发展计划。积极的咨询和额外的指导将来自A.John Rush博士(抗抑郁药临床试验设计和执行方面的培训)、Bruce G.Pollock博士(抗抑郁药遗传学方面的培训)、Joseph D.Terweiger博士(遗传流行病学方面的培训)、John Keilp博士(神经心理测试使用方面的培训)和Eva Petkova博士(统计分析方法方面的培训)。这一以患者为导向的职业发展奖将为首席研究员提供必要的进一步经验和技能,以整合抑郁症和自杀临床试验研究领域的临床和科学专业知识。该奖项的长期目标是让候选人成为抑郁症治疗方面的专家和独立的临床研究人员,特别关注自杀预防。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael F Grunebaum其他文献
Michael F Grunebaum的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael F Grunebaum', 18)}}的其他基金
IM Ketamine for rapid reduction of suicidal thoughts in high-risk emergency room patients: a midazolam-controlled trial
肌内注射氯胺酮可快速减少高危急诊室患者的自杀念头:一项咪达唑仑对照试验
- 批准号:
10469693 - 财政年份:2020
- 资助金额:
$ 17.69万 - 项目类别:
IM Ketamine for rapid reduction of suicidal thoughts in high-risk emergency room patients: a midazolam-controlled trial
肌内注射氯胺酮可快速减少高危急诊室患者的自杀念头:一项咪达唑仑对照试验
- 批准号:
10264940 - 财政年份:2020
- 资助金额:
$ 17.69万 - 项目类别:
Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in Depression
氯胺酮与咪达唑仑:测试快速缓解抑郁症自杀风险
- 批准号:
8400023 - 财政年份:2012
- 资助金额:
$ 17.69万 - 项目类别:
Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in Depression
氯胺酮与咪达唑仑:测试快速缓解抑郁症自杀风险
- 批准号:
8505545 - 财政年份:2012
- 资助金额:
$ 17.69万 - 项目类别:
Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in Depression
氯胺酮与咪达唑仑:测试快速缓解抑郁症自杀风险
- 批准号:
8658478 - 财政年份:2012
- 资助金额:
$ 17.69万 - 项目类别:
Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in Depression
氯胺酮与咪达唑仑:测试快速缓解抑郁症自杀风险
- 批准号:
8837538 - 财政年份:2012
- 资助金额:
$ 17.69万 - 项目类别:
Paroxetine/Bupropion in Suicide Attempters/Ideators with Major Depression
帕罗西汀/安非他酮治疗患有重度抑郁症的自杀未遂者/思想家
- 批准号:
7762711 - 财政年份:2006
- 资助金额:
$ 17.69万 - 项目类别:
Fluoxetine/Bupropion Suicide Attempters Major Depressive
氟西汀/安非他酮自杀未遂者重度抑郁症
- 批准号:
7024808 - 财政年份:2006
- 资助金额:
$ 17.69万 - 项目类别:
Fluoxetine Versus Bupropion in Suicide Attempters With Major Depressive Disorder
氟西汀与安非他酮治疗患有重度抑郁症的自杀未遂者
- 批准号:
7344787 - 财政年份:2006
- 资助金额:
$ 17.69万 - 项目类别:
Paroxetine/Bupropion in Suicide Attempters/Ideators with Major Depression
帕罗西汀/安非他酮治疗患有重度抑郁症的自杀未遂者/思想家
- 批准号:
7563229 - 财政年份:2006
- 资助金额:
$ 17.69万 - 项目类别:
相似海外基金
Relationship between two types of narcissism, anger, aggressive behavior and adaptation
两种自恋、愤怒、攻击行为和适应之间的关系
- 批准号:
23K18995 - 财政年份:2023
- 资助金额:
$ 17.69万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Molecular biomarkers of future aggressive behavior in pituitary tumors
垂体瘤未来攻击行为的分子生物标志物
- 批准号:
10650948 - 财政年份:2023
- 资助金额:
$ 17.69万 - 项目类别:
Neuronal mechanisms of visually-driven aggressive behavior
视觉驱动攻击行为的神经机制
- 批准号:
9978478 - 财政年份:2020
- 资助金额:
$ 17.69万 - 项目类别:
Development of a Nursing Intervention Model to Prevent Aggressive Behavior in Hospitalized Elderly Patients with Dementia
预防住院老年痴呆症患者攻击行为的护理干预模型的建立
- 批准号:
20K23236 - 财政年份:2020
- 资助金额:
$ 17.69万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Development of a Management Sheet on Aggressive Behavior for Working with Patients in a Psychiatric Ward
为精神科病房的患者制定攻击行为管理表
- 批准号:
18K10309 - 财政年份:2018
- 资助金额:
$ 17.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Social determinants of corticolimbic development and aggressive behavior
皮质边缘发育和攻击行为的社会决定因素
- 批准号:
9765038 - 财政年份:2018
- 资助金额:
$ 17.69万 - 项目类别:
Examination of factors that promote and suppress aggressive behavior on the Internet
检查促进和抑制互联网上攻击行为的因素
- 批准号:
17K04438 - 财政年份:2017
- 资助金额:
$ 17.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identifying patterns and mechanistic pathways from violence exposure trajectories to aggressive behavior and psychological disorders
识别从暴力暴露轨迹到攻击行为和心理障碍的模式和机制路径
- 批准号:
9372567 - 财政年份:2017
- 资助金额:
$ 17.69万 - 项目类别:
EAPSI: The Role of Monoamine Oxidase - A Gene Polymorphism in Aggressive Behavior in Macaques
EAPSI:单胺氧化酶的作用 - 基因多态性在猕猴攻击行为中的作用
- 批准号:
1713932 - 财政年份:2017
- 资助金额:
$ 17.69万 - 项目类别:
Fellowship Award
analysis on genetic abnormality related to aggressive behavior of uterine leiomyosarcoma
子宫平滑肌肉瘤侵袭行为相关基因异常分析
- 批准号:
16K11124 - 财政年份:2016
- 资助金额:
$ 17.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)