Pilot Testing a Peer-based Intervention for Symptom Management-HIV

描述(由申请人提供)：本培训资助申请(F31)的目的是提供博士前支持，使研究人员能够测试基于同伴的行为改变干预措施，以帮助患有艾滋病毒的妇女控制一般症状、心理社会症状和妇科症状。具体地说，申请人希望确定拟议的基于同伴的症状管理干预(PRISM-HIV)计划是否降低了症状强度，增加了自我效能感，并提高了艾滋病毒阳性妇女的生活质量。理论：将指导干预的发展和基于同伴的实施的理论框架是班杜拉的社会认知理论、理性行动理论和参与式教育理论。方法：这项研究设计是一项随机对照试验(RCT)，124名患有HIV疾病的妇女在两次基线测量后被随机分为两种情况之一。这两个条件是实验条件，将接受以艾滋病毒症状管理为重点的同伴干预，以及对照条件，将接受为期六个月的常规护理。分析：数据将通过独立、重复测量的方差分析进行分析。在研究结束时，我们将探索因变量(症状强度、自我效能感和生活质量)的潜在差异。这些分析将使学生调查员能够回答研究的主要问题，即同伴带头的症状管理干预的可行性和有效性。重要意义：美国感染艾滋病毒的妇女人数有所增加。随着美国妇女中艾滋病毒疾病负担的增加，对艾滋病毒携带者及其所在社区的健康来说，对基于社区的慢性护理干预的需求变得更加迫切。拟议的干预措施将有助于满足这一需求。与美国国立卫生研究院的目标相关：该申请在以下方面符合美国国立卫生研究院的目标。它允许申请者将现有的生物行为知识应用于一个新的研究领域，即艾滋病毒感染妇女的慢性症状管理；它将通过提供关于预防艾滋病毒传播和艾滋病毒相关疾病的信息，提供关于我们预防疾病的能力的新信息；它将扩大我们对社区干预的知识，这种干预有可能减少美国艾滋病毒疾病的经济负担；它将以负责任的方式进行，在科学行为中促进科学诚信、公共问责和社会责任。

DESCRIPTION (provided by applicant): The purpose of this training grant application (F31) is to provide the predoctoral support to allow the investigator to test a peer-based, behavior change intervention to help women living with HIV disease control general, psychosocial and gynecological symptoms. Specifically, the applicant wants to determine if the proposed peer-based intervention for Symptom Management (PRISM-HIV) program reduces symptom intensity, increases perceived self-efficacy and increases quality of life in HIV positive women. Theory: The theoretical frameworks that will guide the development and peer based implementation of the intervention are Bandura's Social Cognitive Theory, Theory of Reasoned Action, and the Theory of Participatory Education. Methods: The study design is a randomized controlled trial (RCT) with 124 women living with HIV disease will be randomized into one of two conditions following two baseline measurements. The two conditions are the experimental condition which will receive the peer-based intervention focusing on HIV symptom management and the control condition which will receive usual care for the six months. Analysis: The data will be analyzed by separate, repeated measures analysis of variance. We will explore the potential differences in the dependent variables (symptom intensity, perceived self-efficacy and the quality of life) at the conclusion of the study. These analyses will allow the student investigator to answer the main question of the study, i.e. the feasibility and effectiveness of the peer-led symptom management intervention. Significance: There is an increase in the number of women living with HIV disease in the United States. As the burden of HIV disease among U.S women increases, the need for community based, and chronic care interventions becomes more imperative to the health of those living with HIV and the communities in which they live. The proposed intervention would help to meet this need. Relevance to NIH goals: This application meets the goals of the National Institutes of Health in the following ways. It allows the applicant to apply current biobehavioral knowledge to a new research area, chronic symptom management in women living with HIV; it will provide new information on our ability to prevent disease by providing information on preventing HIV transmission and HIV-related diseases; it expands our knowledge on a community-based intervention that has the potential to decrease economic burden of HIV diseases in the Unites States; and it will be conducted in a responsible manner that promotes scientific integrity, public accountability and social responsibility in the conduct of science.