CONSENT TO PARTICIPATE AS A DONOR OF PERIPHERAL BLOOD MONONUCLEAR CELLS

同意作为外周血单核细胞捐献者

• 批准号: 7603442
• 负责人: STANLEY R. RIDDELL
• 金额: $ 1.4万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603442
• 关键词: Acquired Immunodeficiency Syndrome; Adoptive Immunotherapy; Adoptive Transfer; Cells; Computer Retrieval of Information on Scientific Projects Database; Consent; Development; Enrollment; Funding; Grant; Growth; Growth Factor; Harvest; Immune; Immune response; Immunity; In Vitro; Institution; Leukapheresis; Malignant Neoplasms; Numbers; Nutrient; Peripheral Blood Mononuclear Cell; Protocols documentation; Research; Research Personnel; Resources; Source; T-Lymphocyte; United States National Institutes of Health; Virus Diseases; base; cell growth; improved; irradiation; novel; prevent; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS related: Novel therapies based on the adoptive transfer of unmodified or genetically modified T cells are being developed by several investigators to restore or improve host immune responses to viral infection and malignancy. The growth of T cells in vitro to numbers sufficient to modulate host immunity requires the addition of large numbers of feeder cells to the cultures to provide nutrients and growth factors. Peripheral blood mononuclear cells (PBMC) harvested from normal donors by leukapheresis and then subjected to gamma irradiation to prevent cell growth have been identified as an excellent source of feeder cells and are needed for the development of specific adoptive immunotherapy. This protocol enrolls normal volunteer donors for leukapheresis to obtain PBMC for use in developing immune-based therapies

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 艾滋病相关：一些研究人员正在开发基于未修饰或遗传修饰的T细胞过继转移的新疗法，以恢复或改善宿主对病毒感染和恶性肿瘤的免疫应答。T细胞在体外生长到足以调节宿主免疫的数量需要向培养物中添加大量饲养细胞以提供营养物和生长因子。通过白细胞分离术从正常供体收获的外周血单核细胞（PBMC），然后进行γ照射以防止细胞生长，已被鉴定为饲养细胞的极好来源，并且是开发特异性过继免疫疗法所需的。该方案招募正常志愿者供体进行白细胞去除术，以获得PBMC用于开发基于免疫的疗法