A Novel Liquid Oxygen Recharger for Home Oxygen Therapy

用于家庭氧疗的新型液氧充电机

• 批准号: 7221234
• 负责人: JAY C ROZZI
• 金额: $ 50.82万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7221234
• 关键词: Address; Adherence; Age; Aging; Agreement; Air; Area; Budgets; Businesses; Capital; Ceramics; Characteristics; Chronic; Chronic Obstructive Airway Disease; Clinical; Development; Devices; Effectiveness; Engineering; Environment; Equipment; Evaluation; Expenditure; Gases; Generations; Growth; Health; Health Care Costs; Healthcare Systems; Heating; Height; Home environment; Hour; Hypoxemia; LOX gene; Laboratories; Letters; Life; Liquid substance; Maintenance; Marketing; Mechanics; Medical center; Membrane; Military Personnel; Miniaturization; Nitrogen; Numbers; Oxides; Oxygen; Oxygen Therapy Care; Patients; Performance; Personal Satisfaction; Phase; Population; Positioning Attribute; Procedures; Production; Protein-Lysine 6-Oxidase; Published Comment; Rate; Research Infrastructure; Rights; Running; Rural; Safety; Sales; Services; Societies; Solutions; Source; Stream; Supervision; System; Technology; Temperature; Testing; Thermodynamics; Treatment Protocols; United States; United States National Aeronautics and Space Administration; Vent; Work; base; commercial application; commercialization; concept; cost; demographics; design; experience; human subject; improved; innovation; insight; metropolitan; milligram; miniaturize; molecular sieving; novel; novel strategies; patient oriented research; portability; preference; pressure; prototype; research and development; research facility; research study; sensor; size; success; technological innovation; usability; wasting

DESCRIPTION (provided by applicant): The specific aim of this project is to develop and demonstrate a low-cost, liquid oxygen (LOX) generation system to support ambulatory patients using Home Oxygen Therapy (HOT). Currently in the United States, yearly expenditures on HOT are nearly two billion dollars. These expenditures will increase dramatically over the next ten years due to the aging baby-boomer generation. The increase in use of LOX- based HOT systems is expected to continue due to demographics, patient and clinician preferences, and the general success of HOT as a treatment regimen. The primary drawback of LOX-based systems is the high-operational cost, because the storage reservoir for these systems must be frequently refilled with LOX. Creare's innovation is a Miniaturized LOX Generation System (MLGS). This novel device is a small, low-power, low-cost system that generates liquid oxygen from atmospheric air. The basis of the innovation is the miniaturization of the liquid oxygen systems we have developed for the military and NASA. Our novel system will directly refill the portable LOX unit, eliminating the need for the storage reservoir and the LOX re-supply infrastructure. Thus, our innovation will substantially reduce the cost of LOX-based HOT, while improving convenience, safety, and compliance. During Phase I, we clearly demonstrated the feasibility of our innovation and exceeded our technical objectives by designing, demonstrating, and optimizing a highly compact proof-of-concept system for the production of high-purity (>99%) LOX in excess of the original design flow rate. We also completed the preliminary design of a prototype that will be used for the refilling of a commercially available portable LOX unit. We have reached an agreement with a leading supplier of LOX- based HOT systems for the sales and marketing of our innovation. During Phase II, we will design, fabricate, and test the MLGS prototype and transition our innovation to our partner for commercialization.

描述（由申请人提供）：本项目的具体目标是开发和演示一种低成本的液氧（LOX）生成系统，以支持使用家庭氧疗（HOT）的非卧床患者。目前在美国，每年在HOT上的支出接近20亿美元。由于婴儿潮一代的老龄化，这些支出将在未来十年内急剧增加。由于人口统计学、患者和临床医生的偏好以及HOT作为治疗方案的普遍成功，预计基于LOX的HOT系统的使用将继续增加。基于LOX的系统的主要缺点是高操作成本，因为这些系统的储存容器必须频繁地用LOX再填充。Creare的创新是一个小型液氧发生系统（MLGS）。这种新型装置是一种小型、低功耗、低成本的系统，可以从大气中产生液氧。创新的基础是我们为军方和NASA开发的液氧系统的小型化。我们的新系统将直接补充便携式液氧装置，消除了对储存库和液氧再供应基础设施的需要。因此，我们的创新将大大降低基于LOX的HOT的成本，同时提高便利性，安全性和合规性。在第一阶段，我们通过设计、演示和优化一个高度紧凑的概念验证系统，以超过原始设计流量的方式生产高纯度（>99%）LOX，从而清楚地证明了我们创新的可行性，并超越了我们的技术目标。我们还完成了原型的初步设计，该原型将用于商用便携式LOX装置的再填充。我们已经与一家领先的液氧热系统供应商达成协议，以销售和营销我们的创新。在第二阶段，我们将设计，制造和测试MLGS原型，并将我们的创新转移到我们的商业化合作伙伴。