Growth factor directed developmental and pathological lymphangiogenesis

新淋巴管的形成既发生在正常发育过程中，也发生在癌症和心血管疾病的病变组织中。我们已经了解了淋巴在发育过程中是如何形成的，但我们对它们在疾病中是如何形成的了解甚少。该项目将采用多学科方法，包括遗传学和计算生物学，来比较淋巴在发育和疾病中的形成方式。我们希望找到新的方法来操纵这一过程，以获得治疗效果。

The formation of new lymphatic vessels occurs in normal development and in diseased tissues in cancer and cardiovascular disease. We have developed an understanding of how lymphatics form in development but we understand far less about how they form in disease. This project will apply multidisciplinary approaches, including genetics and computational biology, to compare how lymphatics form in development and disease. We hope to uncover new ways to manipulate this process for therapeutic gain.