Molecular Imaging and Targeted Therapy of HER2-Positive

HER2阳性的分子影像和靶向治疗

• 批准号: 7338810
• 负责人: jacek capala
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7338810
• 关键词: Molecular; Imaging; Targeted; Therapy; HER2

Affibody-AlexaFluor conjugates have been developed in and tested in vitro. In vivo studies await arrival of our new Xenogen imaging system. Methods for 18F labeling of Affibody molecules are being developed in collaboration with Dale Kiesewetter. Thermosensitive liposomes have been developed and characterized. Methodology for conjugation of these liposomes with targeting molecules (Affibody of scFv) is being developed in collaboration with Anu Puri and Robert Blumenthal.

Affibody-AlexaFluor偶联物已在体外开发和测试。体内研究等待我们新的Xenogen成像系统的到来。用于Affibody分子的18F标记的方法正在与Dale Kiesewetter合作开发。热敏脂质体已开发和表征。与Anu Puri和Robert布卢门塔尔合作开发了这些脂质体与靶向分子（scFv的亲和体）缀合的方法。