Gated Optical DetectorsDose Guided Radiotherapy

幻影研究已经完成。已经发表了初步研究报告，正在准备对剂量学参数进行全面评估。有限的临床评估正在进行中，以确定与传统的体内测量方法相比，该系统的日常效用。有一个后续的三个阶段的项目，以开发一个探测器阵列剂量引导放射治疗，或DGR。第一阶段是将纤维阵列发展成矩形或螺旋网格，并研究放射治疗期间产生的剂量图以及器官或光束定位的微小变化的影响。II期是了解相对于患者解剖位置的信号变化的含义，如果检测到的信号与参考值有预先确定的容限差异，则中断治疗。第三阶段是将网格信号的变化与辐射场的校正变化动态联系起来，实现对辐射治疗的在线、动态剂量控制。

Phantom studies have been performed. Preliminary studies have been published and a comprehensive assessment of dosimetric parameters is in preparation. Limited clinical assessment is underway to determine the day-to-day utility of this system as compared with conventional in-vivo measurement methods.There is a follow-on three phase project to develop a detector array for dose-guided radiotherapy, or DGR. Phase I is to develop an array of fibers as either a rectangular or spiral grid and study the dose map generated during radiotherapy and the effect of small changes in organ or beam positioning. Phase II is to understand the meaning of signal change relative to the patient's anatomical position and to interrupt the treatment if detected signals differ from reference values by a predetermined tolerance margin. Phase III is to dynamically link the changes in grid signals to corrective changes in the radiation field for on-line, dynamic dose control of radiation treatments.