MOLECULAR ONTOGENY OF ORAL MUCOSAL RESISTANCE TO SIV

口腔粘膜对 SIV 抵抗的分子个体发生

• 批准号: 7349715
• 负责人: MICHAEL E SELSTED
• 金额: $ 15.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349715
• 关键词: MOLECULAR; ONTOGENY; ORAL; MUCOSAL; RESISTANCE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: (1) identify age-dependent differences in anti-SIV resistance associated with defensins, innate immune peptides with antiviral activity, in the oral cavity of rhesus macaques and, (2) determine whether exogenous, topically administered defensins can alter the susceptibility of neonatal rhesus macaques to oral SIV infection.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。目的：（1）确定恒河猴口腔中与防御素（具有抗病毒活性的先天免疫肽）相关的抗 SIV 耐药性的年龄依赖性差异，（2）确定外源性局部施用的防御素是否可以改变新生恒河猴对口腔 SIV 感染的易感性。