Engineering haematopoietic microniches: the hematon project

工程造血微生态位：hematon 项目

• 批准号: BB/D002850/1
• 负责人: Peter Fielden
• 金额: $ 31.14万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD002850%2F1
• 关键词: Engineering; haematopoietic; microniches; hematon; project

Blood is produced in bone marrow. Within bone marrow small clumps of cells have been found, called hematons, which are able to produce all the types of cells found in blood. It is not known how a hematon is able to do this, and the aim of the project is to find out how it does. To do this, we will try to make hematons outside the body. Because we do it outside the body, we can exactly control the composition of the hematon, in terms of the different cell types it consists of as well as the material that is found outside the cells. In addition, we can also precisely control the position of the different cells by guiding them to specific positions within a reconstructed hematon.

血液是在骨髓中产生的。在骨髓中发现了小细胞团，称为血细胞，它能够产生血液中发现的所有类型的细胞。目前还不知道一个hematon是如何做到这一点的，该项目的目的是找出它是如何做到的。为了做到这一点，我们将尝试在体外制造血细胞。因为我们是在体外进行的，所以我们可以精确地控制血液的组成，包括它所包含的不同细胞类型以及细胞外的物质。此外，我们还可以通过将不同细胞引导到重建血液中的特定位置来精确控制它们的位置。

项目成果

The use of electric fields in tissue engineering: A review.

电场在组织工程中的应用：综述。

• DOI: 10.4161/org.5799
• 发表时间: 2008
• 期刊: Organogenesis
• 影响因子: 2.3
• 作者: Markx GH