MULTIPLE MOUSE MRI

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项工作将开发必要的硬件，软件和技术，在MRI系统上成像多个样本。首先，将构建必要的RF线圈、屏蔽和馈电结构，以连接7 T成像系统，并检查各种扫描配置。将采集图像，并通过SNR和采集时间进行表征。最后，将开发必要的后处理软件，以消除重叠和减少由于隔离不良而造成的重影的影响。最终，它将被证明，SNR效率（SNR为一个给定的采集时间相比，一个单一的通道）可以提高一个因素的N（通道的数量）超过一个单一的通道，因此接近理论的最大效率由Bock等人公布。等人（Mag. Res. Med.，49，158-167，2003）。 最初将设计、制造和测试四个线圈。将测量线圈之间的隔离，并表征每个RF线圈的相对质量。将测量接收器链中的无源元件的隔离度和幅度/相位平衡。最终，渠道之间的隔离和平衡将最大化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This work will develop the necessary hardware, software, and techniques for imaging multiple samples on a MRI system. First, the necessary RF coils, shields, and feed structures will be constructed to interface the 7T imaging system and various scanning configurations will be examined. Images will be collected and characterized by SNR and acquisition time. Finally, the necessary post-processing software will be developed to eliminate foldover and reduce the effects of ghost images caused by poor isolation. Ultimately it will be proven that SNR efficiency (SNR for a given acquisition time compared to a single channel) can be improved by a factor of N (number of channels) over that of a single channel, and thus approach the theoretical maximum efficiency published by Bock et. al. (Mag. Res. Med., 49, 158-167, 2003). Initially four coils will be designed, fabricated, and tested. Isolation between coils will be measured and the relative quality of each RF coil will be characterized. The passive components in the receiver chain will be measured for isolation and amplitude/phase balance. Ultimately isolation and balance will be maximized between channels.