FASTEEM II: SPECTROFLUOROMETER FOR REAL TIME DIAGNOSIS OF DISEASE

FASTEEM II：用于疾病实时诊断的荧光分光计

• 批准号: 7357924
• 负责人: JONATHAN NAZEMI
• 金额: $ 3.05万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357924
• 关键词: birth; diagnosis; fluorescence; lasers; lighting

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed the FastEEM II, a second generation portable spectrofluorometer for the real-time, in vivo diagnosis of disease. This system collects reflectance (300 ¿ 800 nm) and laser induced fluorescence (10 excitation wavelengths, 308 ¿ 480 nm) spectra in a fraction of a second (0.3 s). Light delivery and collection is via a fiber optic probe, making the device compatible with many endoscopic procedures. We have developed software using National instruments LabView to control the instrumentation. This software allows for the incorporation of spectral analysis algorithms (being developed separately), which will enable the FastEEM to provide a real-time diagnosis. New electronics and optical layout have increased reliability of this system for clinical use. We are currently working to reduce the size and improve the ¿ease-of-use¿ of this system to make it more compatible with the clinical environment.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们开发了FastEEM II，这是第二代便携式荧光分光光度计，用于实时体内疾病诊断。该系统在几分之一秒（0.3 s）内收集反射（300 <$800 nm）和激光诱导荧光（10个激发波长，308 <$480 nm）光谱。光的传输和收集是通过光纤探头，使该设备与许多内窥镜手术兼容。我们已经开发了软件，使用国家仪器LabView来控制仪器。该软件允许结合光谱分析算法（单独开发），这将使FastEEM能够提供实时诊断。新的电子和光学布局增加了该系统在临床使用中的可靠性。我们目前正在努力减小该系统的尺寸并提高其易用性，使其更适合临床环境。