PROTEOMICS OF AXOPLASMIC SIGNALING COMPLEXES IN HEALTHY AND INJURED NERVES

健康和受损神经轴浆信号复合物的蛋白质组学

• 批准号: 7369034
• 负责人: Michael Fainzilber
• 金额: $ 1.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369034
• 关键词: PROTEOMICS; AXOPLASMIC; SIGNALING; COMPLEXES; HEALTHY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaborative project involves the proteomic characterization of signaling complexes in neuronal cell axoplasm. Two types of complexes are under investigation, those important for long distance communication along the axon, and those involved in localized responses. Both affinity and differential proteomics incorporating advanced mass spectrometry methods are being employed. In addition, mass spectrometric methods are being developed to identify and establish novel posttranslational modifications in neuronal axoplasm protei

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该合作项目涉及神经元细胞轴浆中信号复合物的蛋白质组学表征。两种类型的复合物正在研究中，那些重要的长距离通信沿着轴突，和那些参与本地化的反应。亲和和差异蛋白质组学结合先进的质谱方法正在使用。此外，正在开发质谱方法来鉴定和建立神经元轴浆蛋白质中新的翻译后修饰，