THE INTEGRASE COMPLEX OF TF1, AN LTR-RETROTRANSPOSON OF S POMBE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。ltr -逆转录转座子与逆转录病毒密切相关，并使用许多与逆转录病毒相同的机制进行繁殖。Schizosaccharomyces pombe的ltr -反转录转座子Tf1是一个整合polII转录基因启动子的活性转座子。我们正在鉴定与参与转位的蛋白质结合的蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. LTR-retrotransposons are closely related to retroviruses and propagate using many of the same mechanisms as retroviruses. The LTR-retrotransposon Tf1 of Schizosaccharomyces pombe is an active transposon that integrates at promoters of polII transcribed genes. We are identifying proteins that bind to proteins involved in transposition.