SPINDLE CHECKPOINT PROTEIN INTERACTIONS

纺锤体检查点蛋白质相互作用

• 批准号: 7420747
• 负责人: Kevin S Hardwick
• 金额: $ 1.72万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420747
• 关键词: aneuploidy; centromere; chromosome movement; human; microtubules; model; neoplasm /cancer; proteins; siblings; yeasts

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The spindle checkpoint regulates the metaphase-anaphase transition, and aims to prevent aneuploidy.It responds to defective kinetochore-microtubule interactions by delaying sister chromatid separation and anaphase onset. In so doing it prevents chromosome mis-segregation and the generation of aneuploidy. Aneuploidy is lethal in single-celled organisms such as fission yeast, and is one of the hallmarks of cancer in humans. We are using fission yeast as a model system to study the in vivo dynamics and interactions of the Mad and Bub checkpoint proteins.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。纺锤体检查点调节中期-后期的转换，目的是防止非整倍体，它通过延迟姐妹染色单体分离和后期开始来响应有缺陷的着丝粒-微管相互作用。这样做可以防止染色体错误分离和非整倍体的产生。非整倍性在单细胞生物如分裂酵母中是致命的，并且是人类癌症的标志之一。 我们使用裂殖酵母作为模型系统来研究Mad和Bub检查点蛋白的体内动力学和相互作用。