METABOLITE RATIOMEASURED BY PROTON MRS INCREASE IN VLBW INFANTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。前言：质子磁共振波谱(MRS)是一种非侵入性技术，可以定量测量大脑不同区域的特定代谢物。如果极低出生体重(VLBW)早产儿未能达到足月儿水平，他们在接近足月年龄时代谢物比率的正常变化可能具有诊断和预后价值。这项回溯性研究的目的是获得35至43周龄VLBW早产儿在月经后年龄(PMA，周)之间代谢物比率正常变化的初步数据。方法和讨论：36名在9/01-9/03接受扫描的婴儿符合纳入标准：出生体重1510克，胎龄32周，扫描年龄35-43周。在1.5T扫描机上进行MRI/MRS检查。分析了两个感兴趣的区域的代谢物光谱：1)左右丘脑和基底神经节的结合，以及2)左右皮质。对胆碱(CH)、肌酸和磷酸肌酸(Cr)以及N-乙酰天冬氨酸(NAA)峰进行积分，计算CH/Cr、NAA/Cr和NAA/CH的比值。18~24个月时采用贝利婴幼儿发育量表中的智力发育指数(MDI)和精神运动发育指数(PDI)进行评定。36例中，MDI正常24例，PDI正常26例。致谢：卢卡斯基金会儿科研究会，NIH RR09784，CA48269

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Proton magnetic resonance spectroscopy (MRS) is a noninvasive technique that quantitatively measures specific metabolites in various regions of the brain. Normal changes in metabolite ratios near term age in very low birth weight (VLBW) preterm infants may have diagnostic and prognostic value if they fail to attain term infant levels. The purpose of this retrospective study was to obtain preliminary data on normal changes in metabolite ratios between 35 and 43 postmenstrual age (PMA,weeks) in VLBW preterm infants. Methods and Discussion: Thirty-six infants scanned between 9/01-9/03 met the inclusion criteria: birth weight ?1510g, gestational age ?32 weeks, and scan age of 35-43 postmenstrual weeks. MRI/MRS was performed on a 1.5 T scanner. Metabolite spectra were analyzed in two regions of interest: 1) combined left and right thalamus and basal ganglia, and 2) left and right cortex. Choline (Ch), creatine and phosphocreatine (Cr), and N-acetylaspartate (NAA) peaks were integrated and the ratios of Ch/Cr, NAA/Cr, and NAA/Ch were calculated. Patients were assessed at 18-24 months by the Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) of the Bayley Scales of Infant Development II. From the 36 infants, 24 had a normal MDI (? 85) and 26 had normal PDI ((? 85). Acknowledgements: Pediatric Research Society, Lucas Foundation, NIH RR09784, CA48269