METABOLITE RATIOMEASURED BY PROTON MRS INCREASE IN VLBW INFANTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。质子磁共振波谱（MRS）是一种非侵入性技术，可以定量测量大脑不同区域的特定代谢物。极低出生体重（VLBW）早产儿近月龄代谢物比率的正常变化，如果未能达到足月婴儿水平，可能具有诊断和预后价值。本回顾性研究的目的是获得VLBW早产儿月经后35 - 43岁（PMA，周）代谢物比率正常变化的初步数据。方法与讨论：9/01-9/03期间扫描的36例婴儿符合纳入标准：出生体重？1510g，胎龄？32周，月经后35-43周扫描年龄。在1.5 T扫描仪上进行MRI/MRS检查。在两个感兴趣的区域分析代谢物谱：1)左右丘脑和基底节区，2)左右皮层。对胆碱（Ch）、肌酸和磷酸肌酸（Cr）、n -乙酰天冬氨酸（NAA）峰进行积分，计算Ch/Cr、NAA/Cr和NAA/Ch比值。在18-24个月时采用贝利婴儿发育量表II中的精神发展指数（MDI）和精神运动发展指数（PDI）对患者进行评估。在36名婴儿中，24名MDI正常(？85例，26例PDI正常(？85)。致谢：儿科研究学会，卢卡斯基金会，NIH RR09784, CA48269

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Proton magnetic resonance spectroscopy (MRS) is a noninvasive technique that quantitatively measures specific metabolites in various regions of the brain. Normal changes in metabolite ratios near term age in very low birth weight (VLBW) preterm infants may have diagnostic and prognostic value if they fail to attain term infant levels. The purpose of this retrospective study was to obtain preliminary data on normal changes in metabolite ratios between 35 and 43 postmenstrual age (PMA,weeks) in VLBW preterm infants. Methods and Discussion: Thirty-six infants scanned between 9/01-9/03 met the inclusion criteria: birth weight ?1510g, gestational age ?32 weeks, and scan age of 35-43 postmenstrual weeks. MRI/MRS was performed on a 1.5 T scanner. Metabolite spectra were analyzed in two regions of interest: 1) combined left and right thalamus and basal ganglia, and 2) left and right cortex. Choline (Ch), creatine and phosphocreatine (Cr), and N-acetylaspartate (NAA) peaks were integrated and the ratios of Ch/Cr, NAA/Cr, and NAA/Ch were calculated. Patients were assessed at 18-24 months by the Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) of the Bayley Scales of Infant Development II. From the 36 infants, 24 had a normal MDI (? 85) and 26 had normal PDI ((? 85). Acknowledgements: Pediatric Research Society, Lucas Foundation, NIH RR09784, CA48269