Harnessing Extracellular Matrix Remodelling by Cancer-Associated Fibroblasts to Increase T Cell Infiltration of Solid Tumours

利用癌症相关成纤维细胞的细胞外基质重塑来增加实体瘤的 T 细胞浸润

• 批准号: nhmrc : 2003139
• 金额: $ 92.34万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-extracellular-matrix-solid-tumours/1780068
• 关键词: Harnessing; Extracellular; Matrix; Remodelling; Cancer

The ability of killer T cells to find and eliminate tumour cells is the basis for adoptive transfer immunotherapies, which thus far only work well with blood-borne cancers. There is limited success with solid tumours, which T cells do not readily infiltrate, notably because of remodelling by fibroblasts. We have discovered that T cells migrate in tunnels dug in the tumour matrix by fibroblasts. Here, we will harness this discovery to improve tumour infiltration and rejection of solid tumours.

杀伤性 T 细胞发现并消灭肿瘤细胞的能力是过继转移免疫疗法的基础，迄今为止，该疗法仅适用于血源性癌症。实体瘤的治疗成功率有限，T 细胞不易渗透实体瘤，特别是由于成纤维细胞的重塑。我们发现 T 细胞在成纤维细胞在肿瘤基质中挖掘的隧道中迁移。在这里，我们将利用这一发现来改善肿瘤浸润和实体瘤的排斥。