权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Function and expression of purinoceptors in white matter astrocytes in situ

原位白质星形胶质细胞嘌呤受体的功能和表达

基本信息

批准号：
BB/D012562/1
负责人：
Arthur Butt
金额：
$ 36.94万
依托单位：
University of Portsmouth
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FD012562%2F1
关键词：
Function expression purinoceptors white matter

项目摘要

Studies on brain function have by and large focussed on neurons. However, the most numerous cells in the central nervous system (CNS) are astrocytes, but we still know little about their functions. Early concepts envisaged astrocytes as passive and unexcitable structural elements, much like the connective tissues of organs in the periphery. However, it is now clear that astrocytes are dynamic cells and communicate with each other by way of intracellular waves of calcium. In addition, astrocytes communicate with each and with neurons using chemical neurotransmitters. A key role for the neurotransmitter ATP has been proposed as diffusible signal between glia and between glia and neurons. In addition, calcium controls multiple intracellular pathways that regulate the function of astrocytes. Notably, ATP-mediated calcium signalling may have a particular role in pathology. We propose to test to perform a comprehensive investigation of the mechanisms and actions of ATP in astrocyte physiology and pathology. This work meets several priorities identified by the Biochemistry and Cell Biology Committee. Three themes have been outlined by this committee, fundamentals of cell biology, the cell and its environment, and specialised cell function. The proposal is relevant to all three of these themes. Astrocytes are specialised cells with many unresolved functions and this project will address the fundamental biological question of how ATP-mediated signalling mechanisms regulates their function. We will examine the expression and function of signalling pathways, which fits the priority area concerned with the biochemical and functional properties of membrane proteins. The information has an important bearing on basic neurobiology, brain development, and CNS damage and disease states.

对大脑功能的研究主要集中在神经元上。然而，在中枢神经系统（CNS）中数量最多的细胞是星形胶质细胞，但我们对它们的功能知之甚少。早期的概念设想星形胶质细胞作为被动和不可兴奋的结构元素，很像周围器官的结缔组织。然而，现在清楚的是，星形胶质细胞是动态细胞，并且通过细胞内钙波相互通信。此外，星形胶质细胞通过化学神经递质与神经元进行交流。神经递质ATP的一个关键作用已被提出作为神经胶质之间和神经胶质与神经元之间的可扩散信号。此外，钙控制多种细胞内途径，调节星形胶质细胞的功能。值得注意的是，ATP介导的钙信号传导可能在病理学中具有特定的作用。我们建议测试进行全面调查的机制和行动的ATP在星形胶质细胞的生理和病理。这项工作符合生物化学和细胞生物学委员会确定的几个优先事项。该委员会概述了三个主题，细胞生物学基础，细胞及其环境，以及专门的细胞功能。该建议与所有这三个主题都有关。星形胶质细胞是具有许多未解决功能的特化细胞，该项目将解决ATP介导的信号传导机制如何调节其功能的基本生物学问题。我们将研究信号通路的表达和功能，这符合与膜蛋白的生物化学和功能特性有关的优先领域。这些信息对基础神经生物学、大脑发育、CNS损伤和疾病状态具有重要意义。