Harnessing macrophage-derived cytokine signalling in skeletal muscle regeneration

利用巨噬细胞衍生的细胞因子信号传导骨骼肌再生

• 批准号: nhmrc : 2001233
• 金额: $ 99.19万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-macrophage-derived-muscle-regeneration/1779735
• 关键词: Harnessing; macrophage; derived; cytokine; signalling

We propose to develop novel therapies and tissue engineering approaches for the treatment of muscle injury and wasting disorders using specific muscle stem cells called satellite cells. Our ultimate aim is to accelerate the development of safe, effective and affordable muscle stem cell-based therapies, in an attempt to lessen the disease burden of muscle wasting disorders. The approach will make use of the novel stem cell activating compounds and immune cells that we have identified.

我们建议开发新的治疗方法和组织工程方法，使用称为卫星细胞的特定肌肉干细胞来治疗肌肉损伤和消瘦障碍。我们的最终目标是加速开发安全、有效和负担得起的基于肌肉干细胞的疗法，试图减轻肌肉萎缩疾病的疾病负担。该方法将利用我们已经确定的新型干细胞激活化合物和免疫细胞。