Core--Research Translation

核心--研究翻译

• 批准号: 7064116
• 负责人: JAMES Edward TROSKO
• 金额: $ 18.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064116
• 关键词: Internet; aromatic hydrocarbon receptor; benzofurans; biomedical facility; carbopolycyclic compound; dioxins; environmental contamination; environmental exposure; halobiphenyl /halotriphenyl compound; meeting /conference /symposium; molecular biology

The Research Translation Core has planned a series of activities that will include collaborations with government agencies, meetings and new websites providing technology transfer and communication to a broad audience as suggested by the SBRP RFA. We have initiated the recruitment of a group of cooperators that include federal and state agencies in Michigan and New Jersey and industrial consortiums in the same states. These documented cooperating units have indicated their interest in participating in technology transfer and we will continue to recruit new cooperators using the same methods we have employed to date. An annual one-day meeting with representatives of the cooperating institutions will be held in which selected projects will present highlights of their research progress. Cooperators will be asked to present their views of research needs in the areas of site remediation and health risk analysis. A generous amount of time will be set aside for individual and group discussions in an attempt to foster agreements and resolve differences. In addition, an international symposium on computational and modeling approaches will be held to enhance the understanding and extent of the health threat from environmental contamination. This activity will be supported using funds from a variety of sources. The meeting will enrich our proposed research program which emphasizes the computational system biology approach spanning from molecule to intact organisms. This approach promises more accurate predictability of impacts on human health resulting from exposure to TCDD-like environmental contaminants. In a different and innovative approach to research translation, a set of molecular tools for use in identifying the capacity of microbial consortia to degrade hazardous chemicals in the environment will be developed in specific projects and cores of the research program. These molecular tools will be placed in a data repository including a website open for public use. The website will contain a variety of tools developed by investigators in this and other programs. These tools will be maintained and kept up to date by incorporating new information as it emerges from our own effort as well that of others. A tutorial will be produced to inform users and instruct them on the use of the tools and information in the repository. This activity will serve research scientists, biodegradation engineers and administrators to make more rapid progress in developing strategies to decontaminate and detoxify sites containing hazardous chemicals.

研究翻译核心计划了一系列活动，其中将包括与 政府机构、会议和新网站，为 根据SBRP RFA的建议，广泛的受众。我们已经开始招募一批 合作伙伴，包括密歇根州和新泽西州的联邦和州机构以及工业财团 在相同的州。这些记录在案的合作单位已表示有兴趣参与 技术转让，我们将继续使用我们现有的方法招募新的合作者 到目前为止已经受雇了。将与合作机构的代表举行为期一天的年度会议 选定的项目将展示其研究进展的亮点。合作者将被要求 介绍他们对现场补救和健康风险分析领域的研究需求的看法。一个 将留出大量时间进行个人和小组讨论，试图促进 达成协议并解决分歧。此外，还举办了一个关于计算和管理的国际研讨会 将采取建模方法，以加强对来自 环境污染。这项活动将利用各种来源的资金予以支持。这个 会议将丰富我们提出的强调计算系统生物学的研究计划 从分子到完整有机体的方法。这种方法保证了更准确的可预测性。 暴露在TCDD类环境污染物中对人类健康的影响。 在研究翻译的一种不同和创新的方法中，一套用于识别 微生物协会降解环境中危险化学品的能力将于#年开发。 研究计划的具体项目和核心。这些分子工具将被放置在一个数据中 存储库包括一个开放给公众使用的网站。该网站将包含由 这个项目和其他项目的调查人员。这些工具将通过以下方式进行维护和更新： 新信息来自我们自己的努力以及其他人的努力。将制作一份教程，以告知 并指导用户如何使用存储库中的工具和信息。这项活动将有助于 研究科学家、生物降解工程师和管理人员在开发方面取得更快进展 对含有危险化学品的场所进行净化和解毒的战略。