Harnessing systems biology by integrating proteomics and immunopeptidomics to understand prostate cancer carcinogenesis, diagnosis and treatment

通过整合蛋白质组学和免疫肽组学来利用系统生物学来了解前列腺癌的癌变、诊断和治疗

• 批准号: nhmrc : 1143366
• 金额: $ 27.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-systems-biology-diagnosis-treatment/1319935
• 关键词: Harnessing; systems; biology; integrating; proteomics

This ECF proposal aims to systematic profile to proteomic compositions of prostate normal, and cancer cells, and utilise such data to develop innovative systems biology models that will enable accurate prediction of tumour associate antigen (TAA) presentation for both aggressive and nonaggressive prostate cancer. The outcomes of this project will generate urgently needed knowledge for understanding TAA presentation and contribute to identification of tractable targets for vaccine development.

该ECF提案旨在对前列腺正常细胞和癌细胞的蛋白质组组成进行系统分析，并利用这些数据开发创新的系统生物学模型，从而能够准确预测侵袭性和非侵袭性前列腺癌的肿瘤相关抗原（TAA）呈递。该项目的成果将产生迫切需要的知识，以了解TAA的介绍，并有助于确定易于处理的疫苗开发目标。