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Mechanisms of dermoskeletal development in fish

鱼类皮肤骨骼发育机制

基本信息

批准号：
7500713
负责人：
SUSAN Lee BASSHAM
金额：
$ 5.67万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2009-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7500713
关键词：
Ablation Address Adolescent Affect Age Agreement Amphibia Animals Anterior Antibodies Apolipoprotein E Apoptosis Basal Cell Base Pairing Benchmarking Binding Blood Bone Development Bone Diseases Calcium Calcium Binding Candidate Disease Gene Cartilage Catfish Cell Proliferation Cell division Cells Cephalic Chickens Chorion Chronology Cichlids Class Code Collaborations Collagen Collagen Fibril Collection Complement Complementary DNA Complex Condition Connective Tissue Coupled Cryoultramicrotomy DNA DNA Sequence Data Defect Dental Enamel Denticle Dentin Depth Dermal Dermis Development Development, Other Dextrans Dorsal Drops Dyes Ear Eels Elements Embryo Embryonic Development Environment Epidermis Epithelial Epithelium Evolution Experimental Designs Failure Feathers Fellowship Fertilization Fiber Fibroblasts Figs - dietary Fishes Fluorescence Fluorescent Dyes Fresh Water Functional RNA GTP-Binding Proteins Gasterosteidae Gasterosteiformes Gene Expression Gene Library Genes Genetic Genome Genomics Genus Hippocampus Growth Hair Health Homologous Gene Human Immigration In Situ In Situ Hybridization Individual Integumentary system Invaded Knowledge Label Lampreys Lasers Lateral Learning Left Life Ligands Location Manuscripts Maps Marines Membrane Mesenchyme Mesoderm Minor Modeling Modification Molecular Molecular Analysis Molecular Genetics Morphogenesis Morphology Mus Mutation Names Neural Crest Neural Crest Cell Numbers Odontogenesis Oligonucleotides Organ Orthologous Gene Osteichthyes Osteoblasts Osteogenesis Otic Vesicle Outcome Parathyroid Hormones Pathway interactions Pattern Pelvis Phenotype Pigments Play Population Positioning Attribute Preparation Primordium Proteins Publishing Receptor Gene Relative (related person)Reporting Research Resources Role SHH gene Salmo trutta Series Shark Side Signal Induction Signal Transduction Signaling Molecule Skeletal system Skin Somites Source Specimen Staging Staining method Stains Stromal Cell-Derived Factor 1 Structure Study models Subcutaneous Tissue Surface System Tail Taxon Techniques Testing Tetraodontidae Texas Time Tissues Tooth structure Transplantation Turtles Vertebral column Vertebrate Biology Vertebrates Visual Week Work Zebrafish alizarin appendage base bone cell type chemokine receptor craniofacial cranium day design developmental genetics dextran ectodysplasin embryo culture exoskeleton genome sequencing human PTH protein in vivo inhibitor/antagonist knock-down lateral line loss of function migration mineralization mutant neuromast notch protein novel null mutation protein B receptor receptor expression receptor function research study sample fixation size soft tissue sonic hedgehog receptor spine bone structure success teleost teleost fish tongue papilla

项目摘要

DESCRIPTION (provided by applicant): Long-standing hypotheses concerning the development and likely evolutionary origin of several classes of vertebrate dermal bone remain untested. Do scales and post-cranial dermal bones of extant fishes share a common evolutionary origin with teeth and fin rays? Do the osteogenic cells that produce scales and plates originate in the trunk neural crest, a tissue widely considered to lack osteogenic potential? What are the inducing tissues and signals that generate the pattern of squamation? I propose to address these questions with an analysis of molecular genetic mechanisms that initiate and pattern the post-cranial bony dermal plates of armored Gasterosteiform fish, the threespine stickleback and gulf pipefish, and with experimental embryological approaches to identify the origins of cells and signals involved in the development of these plates. This analysis will contribute to the field of fish integument development for which little information is currently available. In addition, these experiments are likely to meaningfully inform the study of human craniofacial and bone development, as Gasterosteiform bony plates share structural and developmental similarity with cranial dermal bones.

描述（由申请人提供）：关于几类脊椎动物真皮骨的发育和可能的进化起源的长期假设尚未得到验证。现存鱼类的鳞片和颅后皮骨与牙齿和鳍条有共同的进化起源吗？产生鳞片和骨板的成骨细胞是否起源于躯干神经嵴（一种被广泛认为缺乏成骨潜力的组织）？什么样的诱导组织和信号产生鳞屑的模式？我建议解决这些问题的分子遗传机制的分析，启动和模式的后颅骨真皮板装甲Gasterosteiform鱼，threespine棘鱼和海湾海龙，并与实验胚胎学方法，以确定起源的细胞和信号参与这些板的发展。这一分析将有助于目前信息很少的鱼体壁发育领域。此外，这些实验很可能为人类颅面和骨骼发育的研究提供有意义的信息，因为Gasterosteiform骨板与颅骨真皮骨具有结构和发育相似性。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags.

DOI：
10.1371/journal.pgen.1000862
发表时间：
2010-02-26
期刊：
PLoS genetics
影响因子：
4.5
作者：
Hohenlohe PA;Bassham S;Etter PD;Stiffler N;Johnson EA;Cresko WA
通讯作者：
Cresko WA

SNP discovery and genotyping for evolutionary genetics using RAD sequencing.

DOI：
10.1007/978-1-61779-228-1_9
发表时间：
2011
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
0
作者：
Etter, Paul D;Bassham, Susan;Hohenlohe, Paul A;Johnson, Eric A;Cresko, William A
通讯作者：
Cresko, William A