RESPIRATORY VIRUSES IN PEDIATRIC PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。近年来，研究表明，人异流病毒（hMPV）是儿童呼吸道感染常见表现的重要病原体。然而，hMPV的流行病学尚不清楚。本研究的目的是明确hMPV的流行病学和临床表现。该研究有三个主要的具体目的：具体目的1：确定在急诊科寻求急性呼吸道感染护理的婴儿和儿童人群中hMPV的患病率。具体目的2：比较hMPV儿童的疾病严重程度与其他呼吸道感染原因的儿童的疾病严重程度。零假设是没有临床显著性差异。特定目的3：确定hMPV在毛细支气管炎婴儿中的患病率。假设hMPV在细支气管炎患者中的发病率高于非细支气管炎呼吸道感染患者

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human Metapheumovirus (hMPV) has recently been shown to be an important etiologic agent in common presentations of respiratory infections in children. The epidemiology of hMPV is, however, not well understood. The goal of this study is to define the epidemiology and clinical manifestations of hMPV. The study has three primary specific aims: Specific Aim 1: To determine the prevalence of hMPV in the population of infants and children seeking care for acute respiratory infections in the emergency dept. Specific Aim 2: To compare the severity of disease for children with hMPV with the severity of disease of children with other causes of respiratory infections. The null hypothesis is that there is no clinically significant difference. Specific Aim 3: To determine the prevalence of hMPV amoung infants with bronchiolitis. The hypothesis is that incidence of hMPV is highter among patients with bronchiolitis than those with non-bronchiolitis respiratory infecti