PHASE II STUDY OF XRT + LOW-DOSE TEMOZOLOMIDE FOLLOWED BY TEMOZOLOMIDE + CPT-11

XRT 低剂量替莫唑胺随后是替莫唑胺 CPT-11 的 II 期研究

• 批准号: 7375542
• 负责人: MINESH P. MEHTA
• 金额: $ 1.12万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375542
• 关键词: PHASE; II; STUDY; XRT; LOW

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is closed to accrual. (from www.cancer.gov website) Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as temozolomide and irinotecan, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. This phase II trial is studying how well radiation therapy, temozolomide, and irinotecan work in treating patients with newly diagnosed glioblastoma multiforme.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究已停止招募。 (from www.cancer.gov网站）放射疗法使用高能X射线破坏肿瘤细胞。化疗中使用的药物，如替莫唑胺和伊立替康，以不同的方式阻止肿瘤细胞分裂，使它们停止生长或死亡。放射治疗和化学治疗相结合可以杀死更多的肿瘤细胞。 这项II期试验正在研究放射治疗、替莫唑胺和伊立替康在治疗新诊断的多形性胶质母细胞瘤患者中的效果。