PHYSICAL & METABOLIC ABNORMALITIES OF LIPODYSTROPHY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this investigation is to study patients with various types of lipodystrophies and their family members, to determine the mode(s) of inheritance- and to identify lipodystrophy-related candidate genes. Furthermore, the study will determine the natural course of the disease in patients with lipodystrophies- dystrophies through clinical and laboratory investigations. The study will attempt to answer the following specific questions: 1) Do the inheritance patterns of various forms of lipodystrophy differ? 2) What are the phenotypic variations in patients with various types of lipodystrophies? Do the relatives have milder varieties of lipodystrophy which may not be clinically apparent? 3) What are the peculiarities in the adipose tissue distribution in patients with various types of lipodystrophy? Are there other clinical differences in patients with various types of lipodystrophy? 4) Does the absence of fat from particular anatomical sites in different types of lipodystrophies influence glucose and fatty acid metabolism? 5) Does the absence of fat from particular anatomical site (or excess in other sites) affect lipoprotein lipase levels and thus, plasma triglyceride levels and chylomicron clearance? 6) What are the specific genetic defects in heritable forms of lipodystrophies?