PREVENTION OF MICROGRAVITY-INDUCED STONE RISK

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The broad long-term objective is to evaluate the effectiveness of a countermeasure in the prevention of increased propensity for renal stone formation and skeletal mineral loss sustained during space flight. The hypothesis to be test in this project is that potassium magnesium citrate supplementation will attenuate the increased risk for stone formation and diminish microgravity-induced bone loss. The hypothesis will be tested during five weeks of bedrest in normal volunteers through three specific aims: 1- assess the efficacy of supplementation with potassium magnesium citrate (KMgCit) in preventing microgravity-induced increased risk of renal stone formation 2- evaluate the effect of KMgCit supplementation in averting diminished muscle magnesium and potassium concentrations that may occur during microgravity-induced muscle atrophy and 3- assess the efficacy of supplementation with KMgCit in reducing microgravity-induced increases in bone resorption and urinary calcium losses.