WEIGHT LOSS IN PUBLIC HOSPITAL BREAST CANCER PATIENTS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of the preposed randomized trial are to examine in 50 postmenopausal women with breast cancer the effect of a Therapeutic Lifestyle Change intervention targeting weight loss incorporating a low-calorie diet and moderate intensity exercise program compared to a control condition on: Primary aims: Body weight change and insulin resistance change estimated by: 1) fasting insulin level and 2) Homeostasis Model Assessment (HOMA). Secondary aims: Health-related quality of life and fatigue, adipose tissue: Body Mass Index (BMI), total fat mass (measure via DEXA scan), waist and hip circumference, Sagittal thickness and the ratio of truncal versus peripheral fat. Serum Insulin-Like Growth Factors; IGF-1; IGF-2; Insulin-Like Growth Factor Binding Proteins, IGFBP-1, IGFBP-3; Leptin. Serum estrone, total estradiol, free and bioavailable estradiol, estrone sulphate, total and free testosterone, androsteindione, DHEA, DHEA-S, Sex Hormone Binding Globulin (SHBG).