WEIGHT LOSS IN PUBLIC HOSPITAL BREAST CANCER PATIENTS

公立医院乳腺癌患者的体重减轻

• 批准号: 7376058
• 负责人: ROWAN T. CHLEBOWSKI
• 金额: $ 0.56万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376058
• 关键词: WEIGHT; LOSS; PUBLIC; HOSPITAL; BREAST

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of the preposed randomized trial are to examine in 50 postmenopausal women with breast cancer the effect of a Therapeutic Lifestyle Change intervention targeting weight loss incorporating a low-calorie diet and moderate intensity exercise program compared to a control condition on: Primary aims: Body weight change and insulin resistance change estimated by: 1) fasting insulin level and 2) Homeostasis Model Assessment (HOMA). Secondary aims: Health-related quality of life and fatigue, adipose tissue: Body Mass Index (BMI), total fat mass (measure via DEXA scan), waist and hip circumference, Sagittal thickness and the ratio of truncal versus peripheral fat. Serum Insulin-Like Growth Factors; IGF-1; IGF-2; Insulin-Like Growth Factor Binding Proteins, IGFBP-1, IGFBP-3; Leptin. Serum estrone, total estradiol, free and bioavailable estradiol, estrone sulphate, total and free testosterone, androsteindione, DHEA, DHEA-S, Sex Hormone Binding Globulin (SHBG).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。预先设定的随机试验的具体目的是在50名绝经后乳腺癌女性中检查以减肥为目标的治疗性生活方式改变干预（结合低热量饮食和中等强度运动计划）与对照条件相比对以下方面的影响：主要目的：体重变化和胰岛素抵抗变化，通过1）空腹胰岛素水平和2）稳态模型评估（HOMA）估计。次要目的：健康相关的生活质量和疲劳，脂肪组织：体重指数（BMI），总脂肪量（通过DEXA扫描测量），腰围和臀围，肩胛骨厚度和躯干与外周脂肪的比率。血清胰岛素样生长因子; IGF-1; IGF-2;胰岛素样生长因子结合蛋白，IGFBP-1，IGFBP-3;瘦素。血清雌酮、总雌二醇、游离和生物可利用雌二醇、硫酸雌酮、总睾酮和游离睾酮、雄激素二酮、DHEA、DHEA-S、性激素结合球蛋白（SHBG）。