TYPE 1 DIABETES GENETICS CONSORTIUM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。1型糖尿病遗传联盟(T1DGC)将组织国际努力，以确定决定个人患1型糖尿病风险的基因。1型糖尿病遗传学联合会的科学目标是：1.确定、研究和建立3000个“受影响的同胞对”(ASP)家庭的可再生DNA来源，这些家庭至少有两个1型糖尿病兄弟姐妹、他们的父母和+/-两个非糖尿病兄弟姐妹，用于绘制可能与1型糖尿病相关的基因图谱；2.为科学界创建一个数据库，这将有助于搜索1型糖尿病易感基因；3.提供一个集中的DNA储存库，以便对1型糖尿病的遗传结构和功能进行有针对性的研究；4.评估扩大研究成果的机会，以开发1型糖尿病领域的风险预测、预防和治疗方法。为了实现这些目标，T1DGC将从位于全球五个研究定义的地理区域的兄弟姐妹和三人家庭收集信息和血液样本：亚太地区、欧洲、拉丁美洲、北美和英国。这项研究的最终目标是提供临床和遗传资源，以实现基因鉴定所需的样本量和样本可用性。该联盟将建立一种机制，以确保科学家们共同努力，更好地了解导致1型糖尿病风险的遗传因素。该联盟将更好地了解疾病机制，目的是改变1型糖尿病风险人群的这些机制和途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individual's risk for type 1 diabetes. The scientific objectives of the Type 1 Diabetes Genetics Consortium are: 1. To ascertain, study and establish a renewable source of DNA on 3000 "affected sib-pair" (ASP) families with at least two type 1 diabetic siblings, their parents, and +/- up to two non-diabetic siblings for studies to map genes that may be associated with type 1 diabetes; 2. To create a database for the scientific community that would facilitate the search for type 1 diabetes susceptibility genes; 3. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; 4. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of type 1 diabetes. To meet these objectives, the T1DGC will collect information and blood samples from sib-pair and trio families located in five study-defined geographic areas worldwide: Asia-Pacific, Europe, Latin America, North America, and the United Kingdom. The ultimate goal of this study is to provide the clinical and genetic resources to achieve the necessary sample size and sample availability for gene identification. The Consortium will establish a mechanism to ensure that scientists will work together toward a better understanding of the genetic factors that underlies risk for type 1 diabetes. The Consortium will gain a better understanding of disease mechanisms, with a purpose of altering these mechanisms and pathways in individuals at risk of type 1 diabetes.