THE EFFECT OF CHRONIC SILDENAFIL ADMINISTRATION ON BIOCHEMICAL MARKERS

长期服用西地那非对生化标志物的影响

• 批准号: 7376267
• 负责人: VIVIAN A FONSECA
• 金额: $ 0.02万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376267
• 关键词: EFFECT; CHRONIC; SILDENAFIL; ADMINISTRATION; BIOCHEMICAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease is a major cause of morbidity and mortality in patients with diabetes. Endothelial dysfunction has been implicated in the artherogenic process and is present in patients with diabetes much before overt evidence of atherosclerosis. Erectile dysfunction manifests as decreased Flow Mediated Dilatation (FMD), which is a functional abnormality, and abnormal circulating markers which are biochemical abnormalities. Recent data has shown that endothelial dysfunction was improved by sildenafil in heart failure patients. We have preliminary data that indicates improvement of endothelial function in patients with type 2 diabetes. Our hypothesis is that daily treatment with sildenafil will improve biochemical markers of important non-traditional risk factors of cardiovascular disease and thus may play an important role in the prevention and modulation of cardiovascular disease in patients with diabetes. We propose to confirm our hypothesis by pursuing the following specific aim: determine the effect of chronic sildenafil treatment on biochemical markers of endothelial dysfunction (inflammation, oxidative stress) in patients with diabetes.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。心血管疾病是糖尿病患者发病和死亡的主要原因。内皮功能障碍与动脉粥样硬化的发生有关，并且在动脉粥样硬化的明显证据之前就存在于糖尿病患者中。勃起功能障碍表现为作为功能异常的血流介导的舒张功能（FMD）降低，以及作为生化异常的异常循环标志物。最近的数据表明，在心力衰竭患者中，西地那非可改善内皮功能障碍。我们有初步数据表明2型糖尿病患者的内皮功能得到改善。 我们的假设是，每日使用西地那非治疗将改善心血管疾病的重要非传统危险因素的生化标志物，因此可能在预防和调节糖尿病患者的心血管疾病中发挥重要作用。 我们建议通过追求以下具体目标来证实我们的假设：确定慢性西地那非治疗对糖尿病患者内皮功能障碍（炎症，氧化应激）的生化标志物的影响。