THE EFFECT OF CHRONIC SILDENAFIL ADMINISTRATION ON BIOCHEMICAL MARKERS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。心血管疾病是糖尿病患者发病和死亡的主要原因。内皮功能障碍与动脉粥样硬化的形成有关，在动脉粥样硬化的明显证据出现之前，糖尿病患者就存在内皮功能障碍。勃起功能障碍主要表现为血流介导的勃起功能异常(FMD)和循环标志物的异常(生化异常)。最近的数据表明，西地那非可以改善心力衰竭患者的内皮功能障碍。我们有初步数据表明，2型糖尿病患者的内皮功能有所改善。我们的假设是，每日服用西地那非将改善重要的非传统心血管疾病危险因素的生化标志物，从而可能在糖尿病患者心血管疾病的预防和调节中发挥重要作用。我们建议通过追求以下特定目标来证实我们的假设：确定慢性西地那非治疗对糖尿病患者内皮功能障碍(炎症、氧化应激)生化标记物的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease is a major cause of morbidity and mortality in patients with diabetes. Endothelial dysfunction has been implicated in the artherogenic process and is present in patients with diabetes much before overt evidence of atherosclerosis. Erectile dysfunction manifests as decreased Flow Mediated Dilatation (FMD), which is a functional abnormality, and abnormal circulating markers which are biochemical abnormalities. Recent data has shown that endothelial dysfunction was improved by sildenafil in heart failure patients. We have preliminary data that indicates improvement of endothelial function in patients with type 2 diabetes. Our hypothesis is that daily treatment with sildenafil will improve biochemical markers of important non-traditional risk factors of cardiovascular disease and thus may play an important role in the prevention and modulation of cardiovascular disease in patients with diabetes. We propose to confirm our hypothesis by pursuing the following specific aim: determine the effect of chronic sildenafil treatment on biochemical markers of endothelial dysfunction (inflammation, oxidative stress) in patients with diabetes.