THE EFFECT OF CHRONIC SILDENAFIL ADMINISTRATION ON BIOCHEMICAL MARKERS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。心血管疾病是糖尿病患者发病和死亡的主要原因。内皮功能障碍与动脉粥样硬化过程有关，并且在明显的动脉粥样硬化证据出现之前就存在于糖尿病患者中。勃起功能障碍表现为血流介导扩张（FMD）减少，这是一种功能异常，以及循环标志物异常，这是一种生化异常。最近的数据显示，西地那非可改善心力衰竭患者的内皮功能障碍。我们有初步的数据表明2型糖尿病患者内皮功能的改善。我们的假设是，每天服用西地那非可以改善心血管疾病重要非传统危险因素的生化指标，从而可能在糖尿病患者心血管疾病的预防和调节中发挥重要作用。我们提出通过追求以下具体目标来证实我们的假设：确定慢性西地那非治疗对糖尿病患者内皮功能障碍（炎症，氧化应激）生化标志物的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease is a major cause of morbidity and mortality in patients with diabetes. Endothelial dysfunction has been implicated in the artherogenic process and is present in patients with diabetes much before overt evidence of atherosclerosis. Erectile dysfunction manifests as decreased Flow Mediated Dilatation (FMD), which is a functional abnormality, and abnormal circulating markers which are biochemical abnormalities. Recent data has shown that endothelial dysfunction was improved by sildenafil in heart failure patients. We have preliminary data that indicates improvement of endothelial function in patients with type 2 diabetes. Our hypothesis is that daily treatment with sildenafil will improve biochemical markers of important non-traditional risk factors of cardiovascular disease and thus may play an important role in the prevention and modulation of cardiovascular disease in patients with diabetes. We propose to confirm our hypothesis by pursuing the following specific aim: determine the effect of chronic sildenafil treatment on biochemical markers of endothelial dysfunction (inflammation, oxidative stress) in patients with diabetes.