PHASE I CLINICAL AND PHARMACOKINETIC TRIAL OF INTRAPERITONEAL IRINOTECAN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项第一阶段试验的目标是确定每三周通过腹膜途径给药时伊立替康的最大耐受量。它将测定伊立替康的药代动力学，并测定伊立替康的毒性。伊立替康的剂量水平将不断上升，直到出现剂量限制性毒性。每3周重复治疗一次。这是一个机构调查员发起的审判。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this Phase I trial will establish the maximum tolerated dose of Irinotecan when administered by an intraperitoneal route every three weeks. It will determine the pharmacokinetics of intraperitoneal Irinotecan and determine the toxicity profile of intraperitoneal Irinotecan. Dose levels of Irinotecan will be escalated until dose limiting toxicity is seen. Treatment is repeated every 3 weeks. This is an institutional investigator initiated trial.