CANDIDA INFECTION OF THE LACTATING BREAST

哺乳期乳房念珠菌感染

• 批准号: 7377039
• 负责人: JANET Isabel ANDREWS
• 金额: $ 3.66万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377039
• 关键词: CANDIDA; INFECTION; LACTATING; BREAST

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pain associated with breast-feeding is second only to insufficient milk supply as the most common cause for early weaning. Candida infection of the breast has been postulated as one of the causes of breast-feeding associated pain. There is a paucity of data confirming this possible relationship. Persistent nipple pain (after the first two weeks) in lactating women, burning in nature and associated with radiating breast pain during and after feedings, has been linked to Candida infection of the breast. The physiological causes of the infection and treatment options are not well studied. Despite the lack of evidence, there is a growing body of lay literature recommending oral treatment of the nursing infant with nystatin and treatment of the mother with both topical antifungals (nystatin) and systemic antifungals (fluconazole). Our overall hypothesis is that pain associated with breast-feeding is not associated with the presence of Candida. The primary purpose of this research project is to determine the presence of Candida (and/or other pathogens) on the superficial breast (areolar, nipple) and within the ductal architecture in lactating women with and without symptoms breastfeeding-associated pain will also be determined.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。与母乳喂养有关的疼痛是仅次于牛奶供应不足的第二大原因，是早期断奶的最常见原因。乳房念珠菌感染被认为是母乳喂养相关疼痛的原因之一。缺乏数据证实这种可能的关系。哺乳期妇女的持续乳头疼痛（前两周后），性质上是烧灼感，并与哺乳期间和之后的放射性乳房疼痛有关，与乳房念珠菌感染有关。感染的生理原因和治疗方案没有得到很好的研究。尽管缺乏证据，但有越来越多的非专业文献推荐用制霉菌素口服治疗哺乳期婴儿，并用局部抗真菌药（制霉菌素）和全身抗真菌药（氟康唑）治疗母亲。 我们的总体假设是，与母乳喂养相关的疼痛与念珠菌的存在无关。本研究项目的主要目的是确定是否存在念珠菌（和/或其他病原体）的乳房表面（乳晕，乳头）和导管结构内的哺乳期妇女有和没有症状的母乳喂养相关的疼痛也将被确定。