GASTRIC BYPASS EFFECTS ON SLEEP & GLUCOSE REG

胃绕道术对睡眠的影响

• 批准号: 7378613
• 负责人: John C Alverdy
• 金额: $ 1.05万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378613
• 关键词: glucose; glucose tolerance; reduction; sleep; surgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical observations suggest that patients sleep better and feel less sleepy a few days after gastric bypass, ie. Before significant weight reduction. The mechanism is not known. The proposed studies will test the hypotesis that improved glucose tolerance is the mechanism underlying rapid effect of gastric bypass on sleep and sleepiness. Patients undergoing briatric surgery will be studied during two separate 8-day inpatient admissions, one before surgery and one after surgery. On both occasions, dietary intake will be limited to 1,200 Kcal and strictly controlled. Sleep, sleepiness and parameters of glucose tolerance will be assessed at the beginning and at the end of both study p

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。临床观察提示，胃旁路术后几天，患者睡眠较好，嗜睡较少。在显著减轻体重之前。其机制尚不清楚。这项拟议的研究将检验这样一种假设，即改善糖耐量是胃旁路手术快速改善睡眠和嗜睡的机制。接受外科手术的患者将在两次为期8天的住院期间进行研究，一次是在手术前，另一次是在手术后。在这两种情况下，饮食摄入量都将被限制在1,200大卡，并严格控制。睡眠、嗜睡和糖耐量参数将在两项研究开始和结束时进行评估。