CARDIAC MRI IN DIAGNOSIS OF CARDIAC AMYLOIDOSIS (PILOT STUDY)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot observational study seeks to determine whether contrast delayed enhancement (CDE) cardiac magnetic resonance imaging (CMR) is sensitive to abnormal protein deposition and surrounding fibrosis and can thus be used for the early diagnosis of cardiac amyloidosis. The investigators will examine correlations of the amount of CDE with left ventricular systolic function, diastolic dysfunction, ventricular mass and thickness, atrial size, or quantities of immunoglobulin light chains in serum and in urine. Ten patients with amyloidosis demonstrated through biopsy and echocardiogram will undergo