EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项涉及11个亚位点的试点研究，旨在测试NIPPV和营养管理对ALS患者的疗效。6个站点将参与早期NIPPV干预，5个站点将参与营养管理干预，每个站点将招募20名患者。NIPPV研究部门的主要目标是制定和验证提高NIPPV耐受性的策略，确定影响接受这种治疗方式的因素，并评估早期呼吸衰竭的措施。早期营养管理部门的主要目标是开发和验证确定ALS患者能量平衡的方法，这些方法将适用于营养和NIPPV的多中心III期研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study involving 11 sub-sites to test the efficacy with NIPPV and nuturitinoal management in patients with ALS. Six sites will be involved with early NIPPV intervention, and five sites will be involved in nutritional management intervention, and each site will recruit 20 patients. The primary goals of the NIPPV study arm are to develop and validate strategies to improve tolerability of NIPPV, to identify factors that influence acceptance of this treatment modality, and to evaluate measures of early respiratory failure. The primary goals of the early nutrition management arm are to develop and validate methods to determine energy balance in ALS patients that will be applicable to a multicenter Phase III study of nutrition and NIPPV.