OXALIPLATIN (ELOXATIN) WITH BORTEZOMIB IN PATIENTS WITH ADVANCED MALIGNANCY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项联合奥沙利铂和PS-341（一种抑制p53、IkB和其他细胞周期调节蛋白的泛素蛋白酶体降解的抑制剂）治疗晚期癌症的I期试验。目的是确定II期试验所需的最小剂量，并确定这种药物组合的毒性。患者将作为门诊患者接受治疗，并在输注奥沙利铂之前接受加速剂量PS-341的输注。终点是PS-341推荐的II期剂量的确定和剂量限制性毒性的确定。将纳入15-30例晚期癌症患者，器官功能良好，先前未接触过某些类型的药物（沙利度胺，细胞骨架活性药物），参与将涉及26次访问，为期3-6个月。研究者继续招募受试者参加这项研究。目前还没有相关数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a phase I trial of the combination of oxaliplatin and PS-341 (an inhibitor of ubiquitin-proteasome degradation of p53, IkB, and other cell-cycle regulatory proteins) in the treatment of advanced cancer. The goal is to determine the minimal dose requirements for phase II trials and to determine the toxicities of this combination of agents. Patients will be treated as outpatients and will receive infusions of accelerating doses of PS-341 prior to an infusion of oxaliplatin. Endpoints are the identification of a recommended phase II dose of PS-341 and determination of dose-limiting toxicity. 15-30 patients with advanced cancer, good organ function and lack of prior exposure to certain types of agents (thalidomide, cytoskeleton-active agents) will be enrolled, and participation will involve 26 visits for infusions over 3-6 months. The investigators continue to enroll subjects on this study. No data are available as of yet.