PULMONARY GAS FLOW MEASUREMENT USING [3]HE MRI

使用 [3]HE MRI 进行肺气流测量

• 批准号: 7378301
• 负责人: GLYN JOHNSON
• 金额: $ 0.05万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378301
• 关键词: PULMONARY; GAS; FLOW; MEASUREMENT; USING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this protocol are to develop a method of quantifying pulmonary gas flow using inhalation of helium3 and dynamic MRI. This is a developmental study. Volunteers will be imaged by 3HeMRI. 3HeMRI is a radical new method of lung imaging that promises high spatial resolution assessments of lung function that are unavailable by any other technique. With this test the lung airspaces and airways are directly visualized by inhaling the hyperpolarized gas and forming MRI images. Subjects will be instructed to breathe deeply four times and on the final inhalation the 3He will be administered. The investigators believe that the smallest possible volume of inhaled gas, followed by a "chaser" of air, will give the best results. The 3He will not be diluted with nitrogen. The investigators will try doses of 100, 200 and 300 ml of 3He to determine whether the higher signal to noise offered by the greater quantity of gas compensated for the longer bolus. This will be assessed by measuring the signal to noise in calculated flow and volume measurements in the larger vessels. The main focus of the proposal is to develop quantitative methods to analyze the data, based on algorithms designed to evaluate blood flow. The investigators have an approved IND and intend to study 20 normal volunteers. This is a pilot study of what could turn out to be a simple, non-invasive way to examine pulmonary gas flow.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该协议的目标是开发一种使用氦气吸入和动态 MRI 来量化肺气流的方法。这是一项发展研究。志愿者将通过 3HeMRI 进行成像。 3HeMRI 是一种全新的肺部成像方法，可对肺功能进行高空间分辨率评估，这是任何其他技术都无法实现的。通过这项测试，通过吸入超极化气体并形成 MRI 图像，可以直接观察肺空间和气道。将指导受试者深呼吸四次，并在最后一次吸气时进行 3He。研究人员认为，吸入尽可能最小量的气体，然后“追逐”空气，将得到最好的结果。 3He不会被氮气稀释。研究人员将尝试 100、200 和 300 毫升的 3He 剂量，以确定较大气体量提供的较高信噪比是否补偿了较长的推注时间。这将通过测量较大容器中计算的流量和体积测量中的信噪比来评估。该提案的主要重点是开发基于评估血流算法的定量方法来分析数据。研究人员已获得批准的 IND 并打算对 20 名正常志愿者进行研究。这是一项初步研究，旨在寻找一种简单、非侵入性的方法来检查肺部气流。