PARTIAL GROWTH HORMONE INSENSITIVITY IN IDIOPATHIC SHORT STATURE/SMALL-FOR-GESTA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本项目旨在研究特发性身材矮小（ISS）和/或出生胎龄小（SGA）儿童的部分生长激素不敏感（GHI）。我们建议整合功能、生化和分子研究，以确定ISS和/或SGA有部分GHI的儿童最可靠的标记物，以便为他们提供适当的生长激素治疗（比生长激素缺乏儿童给予更高的生长激素剂量）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is to investigate partial growth hormone insensitivity (GHI) among children with idiopathic short stature (ISS) and/or born small-for-gestational age (SGA). We propose to integrate functional, biochemical and molecular studies to identify the most reliable markers for children with ISS and/or SGA that have partial GHI in order to put them on appropriate growth hormone treatment (higher growth hormone doses than are given to growth hormone deficient children).